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Weight management in type 2 diabetes: current and emerging approaches to treatment

Diabetes care, 2015-06, Vol.38 (6), p.1161-1172 [Peer Reviewed Journal]

2015 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. ;Copyright American Diabetes Association Jun 2015 ;ISSN: 0149-5992 ;ISSN: 1935-5548 ;EISSN: 1935-5548 ;DOI: 10.2337/dc14-1630 ;PMID: 25998297 ;CODEN: DICAD2

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Title:
Weight management in type 2 diabetes: current and emerging approaches to treatment
Author: Van Gaal, Luc ; Scheen, André
Subjects: Anti-Obesity Agents - therapeutic use ; Blood Glucose - metabolism ; Cardiovascular disease ; Diabetes ; Diabetes Mellitus, Type 2 - prevention & control ; Diabetic Angiopathies - prevention & control ; Drug Therapy, Combination ; Endocrinologie, métabolisme & nutrition ; Endocrinology, metabolism & nutrition ; Forecasting ; Human health sciences ; Humans ; Hypoglycemic Agents - adverse effects ; Medical treatment ; Obesity ; Obesity - prevention & control ; Pharmacie, pharmacologie & toxicologie ; Pharmacy, pharmacology & toxicology ; Risk Reduction Behavior ; Sciences de la santé humaine ; Weight control ; Weight Gain - drug effects ; Weight Loss - drug effects
Is Part Of: Diabetes care, 2015-06, Vol.38 (6), p.1161-1172
Description: Diabetes is a growing global health concern, as is obesity. Diabetes and obesity are intrinsically linked: obesity increases the risk of diabetes and also contributes to disease progression and cardiovascular disease. Although the benefits of weight loss in the prevention of diabetes and as a critical component of managing the condition are well established, weight reduction remains challenging for individuals with type 2 diabetes due to a host of metabolic and psychological factors. For many patients, lifestyle intervention is not enough to achieve weight loss, and alternative options, such as pharmacotherapy, need to be considered. However, many traditional glucose-lowering medications may lead to weight gain. This article focuses on the potential of currently available pharmacological strategies and on emerging approaches in development to support the glycemic and weight-loss goals of individuals with type 2 diabetes. Two pharmacotherapy types are considered: those developed primarily for blood glucose control that have a favorable effect on body weight and those developed primarily to induce weight loss that have a favorable effect on blood glucose control. Finally, the potential of combination therapies for the management of obese patients with type 2 diabetes is discussed.
Publisher: United States: American Diabetes Association
Language: English
Identifier: ISSN: 0149-5992
ISSN: 1935-5548
EISSN: 1935-5548
DOI: 10.2337/dc14-1630
PMID: 25998297
CODEN: DICAD2
Source: Geneva Foundation Free Medical Journals at publisher websites
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Weight management in type 2 diabetes: current and emerging approaches to treatment

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