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William Maddock Bayliss's therapy for wound shock

Notes and records of the Royal Society of London, 2010-09, Vol.64 (3), p.271-286 [Peer Reviewed Journal]

COPYRIGHT © 2010 The Royal Society ;2010 The Royal Society ;ISSN: 0035-9149 ;EISSN: 1743-0178 ;DOI: 10.1098/rsnr.2009.0068 ;PMID: 20973450

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Title:
William Maddock Bayliss's therapy for wound shock
Author: Van der Kloot, William
Subjects: Animals ; Blood ; Blood plasma ; Blood pressure ; Blood Transfusion ; Cats ; Colloids ; E. H. Starling ; H. H. Dale ; Heart ; History of medicine and histology ; History, 20th Century ; Humans ; Military Medicine - history ; Osmosis ; Osmotic Pressure ; Physiology ; Postoperative Complications - etiology ; Postoperative Complications - therapy ; Shock - etiology ; Shock - therapy ; Veins ; Viscosity ; W. B. Cannon ; W. M. Bayliss ; World War I ; Wound Shock ; Wounds and Injuries - complications ; Wounds and Injuries - history ; Wounds and Injuries - therapy
Is Part Of: Notes and records of the Royal Society of London, 2010-09, Vol.64 (3), p.271-286
Description: During World War I, military surgeons discovered that patients die from wound shock because their blood pressure falls catastrophically. William Maddock Bayliss produced experimental shock by bleeding anaesthetized cats, which lowers their blood pressure. He restored pressure by infusing salt solution containing enough gum acacia to generate the colloid osmotic pressure ordinarily contributed by the plasma proteins. Ernest Henry Starling had demonstrated that as plasma flows through the capillaries the colloid osmotic pressure of its proteins retains water. From 1917 to 1919 Bayliss and Starling served on the Special Investigation Committee on Surgical Shock and Allied Conditions of the Medical Research Committee. Both gum-saline and blood transfusions were used successfully on wound-shocked soldiers, but we do not know how many were treated, and the effectiveness of whole blood in comparison with gum-saline was not ascertained. Today the colloid osmotic pressure in transfusion solutions is usually provided by dextran or human albumin. Vast quantities are used, but Bayliss's role in the development of this clever biophysical therapy has been almost forgotten.
Publisher: England: The Royal Society
Language: English
Identifier: ISSN: 0035-9149
EISSN: 1743-0178
DOI: 10.1098/rsnr.2009.0068
PMID: 20973450
Source: MEDLINE
Alma/SFX Local Collection

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William Maddock Bayliss's therapy for wound shock

COPYRIGHT © 2010 The Royal Society ;2010 The Royal Society ;ISSN: 0035-9149 ;EISSN: 1743-0178 ;DOI: 10.1098/rsnr.2009.0068 ;PMID: 20973450

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