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The gut microbiota and its interactions with cardiovascular disease

Microbial biotechnology, 2020-05, Vol.13 (3), p.637-656 [Peer Reviewed Journal]

2020 The Authors. published by John Wiley & Sons Ltd and Society for Applied Microbiology. ;2020 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology. ;2020. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 1751-7915 ;EISSN: 1751-7915 ;DOI: 10.1111/1751-7915.13524 ;PMID: 31984651

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Title:
The gut microbiota and its interactions with cardiovascular disease
Author: Xu, Hui ; Wang, Xiang ; Feng, Wenke ; Liu, Qi ; Zhou, Shanshan ; Liu, Quan ; Cai, Lu
Subjects: Antibiotics ; Atherosclerosis ; Bacteria ; Bacteria - metabolism ; Bile acids ; Bioactive metabolites ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - microbiology ; Consortia ; Diabetes ; Diet ; Digestive system ; Digestive tract ; Dysbacteriosis ; Dysbiosis - microbiology ; Fatty acids ; Flora ; Gastrointestinal Microbiome - physiology ; Genomes ; Heart diseases ; Heart failure ; Homeostasis ; Humans ; Hypertension ; Inflammation ; Intestinal microflora ; Intestine ; Metabolic pathways ; Metabolism ; Metabolites ; Microbiota ; Microorganisms ; Minireview ; Minireviews ; Pathogenesis ; Pathways ; Peptides ; Permeability ; Physiology ; Risk analysis ; Risk Factors ; Studies ; Therapeutic applications ; Trimethylamine
Is Part Of: Microbial biotechnology, 2020-05, Vol.13 (3), p.637-656
Description: Summary The intestine is colonized by a considerable community of microorganisms that cohabits within the host and plays a critical role in maintaining host homeostasis. Recently, accumulating evidence has revealed that the gut microbial ecology plays a pivotal role in the occurrence and development of cardiovascular disease (CVD). Moreover, the effects of imbalances in microbe–host interactions on homeostasis can lead to the progression of CVD. Alterations in the composition of gut flora and disruptions in gut microbial metabolism are implicated in the pathogenesis of CVD. Furthermore, the gut microbiota functions like an endocrine organ that produces bioactive metabolites, including trimethylamine/trimethylamine N‐oxide, short‐chain fatty acids and bile acids, which are also involved in host health and disease via numerous pathways. Thus, the gut microbiota and its metabolic pathways have attracted growing attention as a therapeutic target for CVD treatment. The fundamental purpose of this review was to summarize recent studies that have illustrated the complex interactions between the gut microbiota, their metabolites and the development of common CVD, as well as the effects of gut dysbiosis on CVD risk factors. Moreover, we systematically discuss the normal physiology of gut microbiota and potential therapeutic strategies targeting gut microbiota to prevent and treat CVD. The fundamental purpose of this review is to summarize recent studies on illustrating the complex interactions between the gut microbiota, their metabolites and the development of common CVD, as well as the effects of gut dysbiosis on CVD risk factors. Moreover, we systematically discuss the normal physiology of gut microbiota and potential therapeutic strategies targeting gut microbiota to prevent and treat CVD.
Publisher: United States: John Wiley & Sons, Inc
Language: English
Identifier: ISSN: 1751-7915
EISSN: 1751-7915
DOI: 10.1111/1751-7915.13524
PMID: 31984651
Source: Journals@Ovid Open Access Journal Collection Rolling
Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
PubMed Central
Wiley Online Library Open Access
ProQuest Central
DOAJ Directory of Open Access Journals

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The gut microbiota and its interactions with cardiovascular disease

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