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Polymorphism of tumor necrosis factor alpha (TNF-alpha) gene promoter, circulating TNF-alpha level, and cardiovascular risk factor for ischemic stroke

Journal of neuroinflammation, 2012-10, Vol.9 (1), p.235-235, Article 235 [Peer Reviewed Journal]

COPYRIGHT 2012 BioMed Central Ltd. ;2012 Cui et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ;Copyright ©2012 Cui et al.; licensee BioMed Central Ltd. 2012 Cui et al.; licensee BioMed Central Ltd. ;ISSN: 1742-2094 ;EISSN: 1742-2094 ;DOI: 10.1186/1742-2094-9-235 ;PMID: 23050663

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Title:
Polymorphism of tumor necrosis factor alpha (TNF-alpha) gene promoter, circulating TNF-alpha level, and cardiovascular risk factor for ischemic stroke
Author: Cui, Guanglin ; Wang, Haoran ; Li, Rui ; Zhang, Lina ; Li, Zongzhe ; Wang, Yan ; Hui, Rutai ; Ding, Hu ; Wang, Dao Wen
Subjects: Adult ; Aged ; Biotechnology industry ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular risk factors ; Cardiovascular system ; Case-Control Studies ; Cell Line, Transformed ; Central nervous system ; Cohort Studies ; Cytokines ; Data processing ; Female ; Function study ; Gene Frequency ; Gene polymorphism ; Genes ; Genetic aspects ; Genetic Linkage ; Genetic polymorphisms ; Genetic Predisposition to Disease ; Genetic research ; Genetics ; Genotype ; Health risks ; Hospitals ; Humans ; Inflammation ; Ischemia ; Ischemia - complications ; Male ; Medical research ; Medicine, Experimental ; Meta-analysis ; Meta-Analysis as Topic ; Middle Aged ; Mutation ; Necrosis ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic - genetics ; Promoters ; Promoters (Genetics) ; Public health ; Reviews ; Risk Factors ; Stroke ; Stroke (Disease) ; Stroke - blood ; Stroke - epidemiology ; Stroke - etiology ; Stroke - genetics ; Studies ; Transfection ; Tumor necrosis factor ; Tumor necrosis factor alpha (TNF-α) ; Tumor necrosis factor- alpha ; Tumor Necrosis Factor-alpha - blood ; Tumor Necrosis Factor-alpha - genetics ; Tumors
Is Part Of: Journal of neuroinflammation, 2012-10, Vol.9 (1), p.235-235, Article 235
Description: Tumor necrosis factor-α (TNF-α) is one of the most typical pro-inflammatory cytokines with both beneficial and destructive properties for the central nervous system. Increasing evidences have demonstrated the important role of TNF-α in the development of ischemic stroke, but studies examining the possible association with stroke or direct functional effects of polymorphisms in TNF-α have been contradictory. In this study, a 2-kb length of the proximal promoter of the TNF-α was screened and four polymorphisms were investigated in the case-control study. Our data confirmed the association between -308G/A variant with stroke in 1,388 stroke patients and 1,027 controls and replicated in an independent population of 961 stroke patients and 821 controls (odds ratio (OR) = 1.34, 95% confidence interval (CI) =1.02 to 1.77 and OR = 1.56, 95% CI = 1.09 to 2.23, respectively). To reconcile the association between polymorphisms and stroke and to give a comprehensive picture of the genetic architecture of this important gene, we performed a meta-analysis of 15 published studies in an Asian population. Our results demonstrated an association between rs1800629 and ischemic stroke (OR = 1.43, 95% CI = 1.21 to 1.69). Another meta-analysis results of 14 studies demonstrated that ischemic stroke patients have higher serum TNF-α level than the control subjects (standardized mean difference (SMD) = 2.33, 95% CI = 1.85 to 2.81). In vitro evaluation of potential interaction between variants of the TNF-α gene (-308G/A, -857C/T, and -1031T/C) demonstrated that these three polymorphisms could interact together to determine the overall activity of the TNF-α gene. These findings strongly implicate the involvement of TNF-α in the pathogenesis of stroke.
Publisher: England: BioMed Central Ltd
Language: English
Identifier: ISSN: 1742-2094
EISSN: 1742-2094
DOI: 10.1186/1742-2094-9-235
PMID: 23050663
Source: Geneva Foundation Free Medical Journals at publisher websites
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Polymorphism of tumor necrosis factor alpha (TNF-alpha) gene promoter, circulating TNF-alpha level, and cardiovascular risk factor for ischemic stroke

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