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Response of antioxidant defense system to chromium (VI)-induced cytotoxicity in human diploid cells

Biometals, 2010-02, Vol.23 (1), p.161-172 [Peer Reviewed Journal]

Springer Science+Business Media, LLC. 2009 ;Springer Science+Business Media, LLC. 2010 ;ISSN: 0966-0844 ;EISSN: 1572-8773 ;DOI: 10.1007/s10534-009-9276-6 ;PMID: 19915997

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Title:
Response of antioxidant defense system to chromium (VI)-induced cytotoxicity in human diploid cells
Author: Asatiani, Nino ; Abuladze, Marina ; Kartvelishvili, Tamar ; Kulikova, Nina ; Asanishvili, Lali ; Holman, Hoi-Ying ; Sapojnikova, Nelly
Subjects: Antioxidants ; Antioxidants - metabolism ; Apoptosis - drug effects ; Biochemistry ; Biomedical and Life Sciences ; Catalase - metabolism ; Cell Biology ; Cell Cycle - drug effects ; Cell Proliferation - drug effects ; Cells ; Cells, Cultured ; Chromium ; Chromium - toxicity ; Diploidy ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Fibroblasts - drug effects ; Fibroblasts - metabolism ; Glutathione Reductase - metabolism ; Humans ; Life Sciences ; Medicine/Public Health ; Microbiology ; Oxidative Stress - drug effects ; Pharmacology/Toxicology ; Plant Physiology ; Reactive Oxygen Species - metabolism ; Structure-Activity Relationship ; Superoxide Dismutase - metabolism ; Toxicity
Is Part Of: Biometals, 2010-02, Vol.23 (1), p.161-172
Description: The aim of this study is to establish antioxidant indicators of chromium toxicity in fetal human lung fibroblasts (HLF). The results obtained corroborate and develop our earlier observation of low-dose and long-term action of Cr(VI) on human cells in culture. In the case of a nontoxic chromium dose, temporary oxidative stress is overcome by increased activity of the antioxidant system with correlation to cell cycle re-entry. The toxic concentrations misbalance the cell antioxidant defense systems and cause irreversible growth arrest and massive cell death by apoptosis. Sub-toxicity is defined as toxicity stretched in time. The activity of GPx (glutathione peroxidase) is proposed as a biomarker of oxidative stress caused by Cr(VI), and the GR (glutathione reductase) inhibition is considered as a marker of the toxicity developed under the complex Cr(VI) action. In HLF cells the glutathione dependent defense system is the first system destroyed in response to toxic chromium action. Only the balance between SOD (superoxide dismutase) and H₂O₂ degrading enzymes (catalase and GPx), should play an important role in the fate of a cell, not individual enzymes.
Publisher: Dordrecht: Dordrecht : Springer Netherlands
Language: English;Dutch
Identifier: ISSN: 0966-0844
EISSN: 1572-8773
DOI: 10.1007/s10534-009-9276-6
PMID: 19915997
Source: MEDLINE
Alma/SFX Local Collection
ProQuest Central

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Response of antioxidant defense system to chromium (VI)-induced cytotoxicity in human diploid cells

Springer Science+Business Media, LLC. 2009 ;Springer Science+Business Media, LLC. 2010 ;ISSN: 0966-0844 ;EISSN: 1572-8773 ;DOI: 10.1007/s10534-009-9276-6 ;PMID: 19915997

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