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Intestinal Metaplasia and the Risk of Gastric Cancer in an Immigrant Asian Population

Clinical Medicine Insights. Gastroenterology, 2012-01, Vol.2012 (5), p.43-50

2012 SAGE Publications. ;COPYRIGHT 2012 Sage Publications Ltd. (UK) ;2012 the author(s), publisher and licensee Libertas Academica Ltd. 2012 ;ISSN: 1179-5522 ;EISSN: 1179-5522 ;DOI: 10.4137/CGast.S10070 ;PMID: 24833933

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  • Title:
    Intestinal Metaplasia and the Risk of Gastric Cancer in an Immigrant Asian Population
  • Author: Abadir, Amir ; Streutker, Catherine ; Brezden-Masley, Christine ; Grin, Andrea ; Kim, Young-In
  • Subjects: Colorectal diseases ; Complications and side effects ; Demographic aspects ; Gastrointestinal diseases ; Original Research ; Risk factors ; Stomach cancer
  • Is Part Of: Clinical Medicine Insights. Gastroenterology, 2012-01, Vol.2012 (5), p.43-50
  • Description: The development of intestinal metaplasia (IM) has been purported to be a critical step in the pathogenesis of gastric cancer. However, the natural history of IM in migrant human populations has not been well elucidated. The purpose of this study was to determine the risk of gastric cancer posed by IM in Asian immigrants undergoing gastric cancer screening. A retrospective review of Asian immigrants found to have IM during screening was conducted over an 18-month period. In total, 222 patients were found to have IM. Altogether, 24% had a history of smoking, 48% had a family history of gastric cancer, and 52% had a history of Helicobacter pylori (H. pylori) infection with a 96% eradication rate. Patients with stable IM (SIM) were then compared with those who developed high risk pathology (HRP), specifically dysplasia and/or adenocarcinoma. Thirty-five patients (16%) were included in the HRP group. 31 with dysplasia (14%) and 4 with adenocarcinoma (2%). Of those with dysplasia, 55% demonstrated regression to IM over the course of follow-up. Patients in the SIM group were more likely to be female (60% vs. 31%, P = 0.002) and more likely to have had a normal biopsy during follow-up (32% vs. 9%, P = 0.005). Odds ratios for IM stability were 3.3 (95% CI 1.5-7.0) and 5.0 (95% CI 1.5-17.1) for female gender and presence of a normal biopsy, respectively. Intestinal metaplasia in immigrant Asian populations is predominantly a stable histologic finding associated with a low rate of persistent dysplasia and adenocarcinoma.
  • Publisher: London, England: Libertas Academica
  • Language: English
  • Identifier: ISSN: 1179-5522
    EISSN: 1179-5522
    DOI: 10.4137/CGast.S10070
    PMID: 24833933
  • Source: Sage Journals GOLD Open Access 2024
    Geneva Foundation Free Medical Journals at publisher websites
    PubMed Central
    Directory of Open Access Journals
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