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regulação da expressão de receptor mediante distribuição de fatores de transcrição artificiais
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Title:
regulação da expressão de receptor mediante distribuição de fatores de transcrição artificiais
Author:
ALBERT NEUTZNER
;
ALICE HUXLEY
;
JOSEF FLAMMER
Subjects:
BEER
;
BIOCHEMISTRY
;
CHEMISTRY
;
COMPOSITIONS THEREOF
;
CULTURE MEDIA
;
ENZYMOLOGY
;
METALLURGY
;
MICROBIOLOGY
;
MICROORGANISMS OR ENZYMES
;
MUTATION OR GENETIC ENGINEERING
;
ORGANIC CHEMISTRY
;
PEPTIDES
;
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
;
SPIRITS
;
VINEGAR
;
WINE
Description:
resumo patente de invenção: "regulação da expressão de receptor mediante distribuição de fatores de transcrição artificiais". a presente invenção refere-se a um fator de transcrição artificial compreendendo uma proteína de dedo de zinco polidáctila que tem como alvo especificamente um promotor de gene de receptor fusionado a um domínio de proteína inibidor ou ativador, uma sequência de localização nuclear e um domínio de transdução de proteína. em exemplos particulares, esses promotores de genes de receptores regulam a expressão do receptor de endotelina a, do receptor de endotelina b, do receptor do tipo toll 4 ou do receptor de ige de alta afinidade. fatores de transcrição artificiais dirigidos para os receptores de endotelina a ou b são úteis no tratamento de doenças moduladas pela endotelina, como doenças cardiovasculares, e, em particular, doenças do olho, por exemplo, oclusão da veia retiniana, oclusão da artéria retiniana, edema macular, neuropatia óptica, coriorretinopatia serosa central, retinite pigmentosa, neuropatia óptica hereditária de leber, e outras. fatores de transcrição artificiais dirigidos para o receptor do tipo toll 4 ou receptor de ige são úteis para o tratamento de transtornos autoimunes, e outros, e transtornos alérgicos, respectivamente. The invention relates to an artificial transcription factor comprising a polydactyl zinc finger protein targeting specifically a receptor gene promoter fused to an inhibitory or activatory protein domain, a nuclear localization sequence, and a protein transduction domain. In particular examples these receptor gene promoters regulate the expression of the endothelin receptor A, the endothelin receptor B, the Toll-like receptor 4 or the high-affinity IgE receptor. Artificial transcription factors directed to the endothelin A or B receptors are useful in the treatment of diseases modulated by endothelin, such as cardiovascular diseases, and, in particular, eye diseases, e.g. retinal vein occlusion, retinal artery occlusion, macular edema, optic neuropathy, central serous chorioretinopathy, retinitis pigmentosa, Leber's hereditary optic neuropathy, and the like. Artificial transcription factors directed to the Toll-like receptor 4 or the IgE receptor are useful for the treatment of autoimmune disorders, and the like, and allergic disorders, respectively.
Creation Date:
2017
Language:
Portuguese
Source:
esp@cenet
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