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Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

Nature genetics, 2014-03, Vol.46 (3), p.234-244 [Peer Reviewed Journal]

COPYRIGHT 2014 Nature Publishing Group ;COPYRIGHT 2014 Nature Publishing Group ;Copyright Nature Publishing Group Mar 2014 ;ISSN: 1061-4036 ;ISSN: 1546-1718 ;EISSN: 1546-1718 ;DOI: 10.1038/ng.2897 ;PMID: 24509480

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Title:
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
Author: Mahajan, Anubha ; Go, Min Jin ; Gaulton, Kyle J ; Prokopenko, Inga ; Wang, Xu ; Abecasis, Goncalo R ; Balkau, Beverley ; Barnett, Anthony H ; Beilby, John ; Bell, Graeme I ; Burtt, Noël ; Chang, Li-Ching ; Chen, Han ; Chidambaram, Manickam ; Chines, Peter S ; Cho, Nam H ; Cho, Young Min ; van Dam, Rob M ; Danesh, John ; Dedoussis, George ; Doney, Alex S ; Donnelly, Peter J ; Emilsson, Valur ; Eriksson, Johan G ; Florez, Jose C ; Forsen, Tom ; Fox, Caroline ; Fraser, Ross M ; Gigante, Bruna ; Grant, George B ; Grundberg, Elin ; Hamsten, Anders ; Hara, Kazuo ; Hattersley, Andrew T ; Herder, Christian ; Hveem, Kristian ; Hydrie, Zafar I ; Ingelsson, Erik ; Islam, Muhammed ; Jackson, Anne U ; Jafar, Tazeen ; Kadowaki, Takashi ; Kang, Hyun Min ; Kao, Wen Hong L ; Kato, Norihiro ; Kelly, Ann M ; Kim, Sangsoo ; Kong, Augustine ; Kraft, Peter ; Kravic, Jasmina ; Kumar, Ashish ; Kuusisto, Johanna ; Lagou, Vasiliki ; Langenberg, Claudia ; Lee, Jen-Mai ; Li, Yun ; Lindholm, Eero ; Loos, Ruth J F ; Maeda, Shiro ; Mägi, Reedik ; Männisto, Satu ; Matthews, David R ; Morris, Andrew D ; Navarro, Pau ; Pankow, James S ; Park, Kyong Soo ; Platou, Carl G ; Qi, Lu ; Rauramaa, Rainer ; Raychaudhuri, Soumya ; Rybin, Denis ; Saaristo, Timo E ; Saltevo, Juha ; Segrè, Ayellet V ; Sennblad, Bengt ; Sigurđsson, Gunnar ; Stefansson, Kari ; Steinthorsdottir, Valgerdur ; Stirrups, Kathleen ; Stringham, Heather M ; Suo, Chen ; Thorleifsson, Gudmar ; Tremoli, Elena ; Tsai, Fuu Jen ; Tuomilehto, Jaakko ; Veglia, Fabrizio ; Wareham, Nicholas J ; Wilsgaard, Tom ; Wilson, James F ; Wong, Tien Yin ; Wu, Ying ; Yamamoto, Ken ; Zhang, Fan ; Zheng, Wei ; Bowden, Donald W ; Cox, Nancy J ; Cruz, Miguel ; Seielstad, Mark ; Parra, Esteban J ; Morris, Andrew P
Subjects: Alleles ; Architecture ; Asian People - genetics ; Basic Medicine ; Case-Control Studies ; Clinical Medicine ; Diabetes ; Diabetes Mellitus, Type 2 - genetics ; Endocrinology and Diabetes ; Endokrinologi och diabetes ; Genealogy ; Genetic aspects ; Genetic Predisposition to Disease ; Genetic research ; Genetic susceptibility ; Genome-Wide Association Study ; Genomes ; Hispanic or Latino - genetics ; Humans ; Immigration ; Klinisk medicin ; Medical and Health Sciences ; Medical Genetics ; Medicin och hälsovetenskap ; Medicinsk genetik ; Medicinska och farmaceutiska grundvetenskaper ; Meta-analysis ; Polymorphism, Single Nucleotide ; Risk Factors ; Type 2 diabetes ; White People - genetics
Is Part Of: Nature genetics, 2014-03, Vol.46 (3), p.234-244
Description: To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant excess in the directional consistency of T2D risk alleles across ancestry groups, even at SNPs demonstrating only weak evidence of association. By following up the strongest signals of association from the trans-ethnic meta-analysis in an additional 21,491 cases and 55,647 controls of European ancestry, we identified seven new T2D susceptibility loci. Furthermore, we observed considerable improvements in the fine-mapping resolution of common variant association signals at several T2D susceptibility loci. These observations highlight the benefits of trans-ethnic GWAS for the discovery and characterization of complex trait loci and emphasize an exciting opportunity to extend insight into the genetic architecture and pathogenesis of human diseases across populations of diverse ancestry.
Publisher: United States: Nature Publishing Group
Language: English
Identifier: ISSN: 1061-4036
ISSN: 1546-1718
EISSN: 1546-1718
DOI: 10.1038/ng.2897
PMID: 24509480
Source: Geneva Foundation Free Medical Journals at publisher websites
AUTh Library subscriptions: ProQuest Central
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Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

COPYRIGHT 2014 Nature Publishing Group ;COPYRIGHT 2014 Nature Publishing Group ;Copyright Nature Publishing Group Mar 2014 ;ISSN: 1061-4036 ;ISSN: 1546-1718 ;EISSN: 1546-1718 ;DOI: 10.1038/ng.2897 ;PMID: 24509480

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