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Vitamin D insufficiency and deficiency with stages of chronic kidney disease in an Asian population

BMC nephrology, 2013-10, Vol.14 (1), p.206-206, Article 206 [Peer Reviewed Journal]

COPYRIGHT 2013 BioMed Central Ltd. ;2013 Satirapoj et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ;Copyright © 2013 Satirapoj et al.; licensee BioMed Central Ltd. 2013 Satirapoj et al.; licensee BioMed Central Ltd. ;ISSN: 1471-2369 ;EISSN: 1471-2369 ;DOI: 10.1186/1471-2369-14-206 ;PMID: 24083392

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Title:
Vitamin D insufficiency and deficiency with stages of chronic kidney disease in an Asian population
Author: Satirapoj, Bancha ; Limwannata, Pokkrong ; Chaiprasert, Amnart ; Supasyndh, Ouppatham ; Choovichian, Panbuppa
Subjects: Aged ; Albumin ; Analysis ; Biomarkers - blood ; Blood pressure ; Causality ; Chronic kidney failure ; Clinical medicine ; Comorbidity ; Confidence intervals ; Family medical history ; Female ; Health aspects ; Hemoglobin ; Hospitals ; Humans ; Kidney diseases ; Kidney Function Tests - statistics & numerical data ; Male ; Metabolites ; Middle Aged ; Older people ; Phosphatases ; Phosphates ; Population ; Prevalence ; Renal Insufficiency, Chronic - blood ; Renal Insufficiency, Chronic - diagnosis ; Renal Insufficiency, Chronic - epidemiology ; Risk Factors ; Thailand - epidemiology ; Type 2 diabetes ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D deficiency ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - diagnosis ; Vitamin D Deficiency - epidemiology ; Vitamin deficiency
Is Part Of: BMC nephrology, 2013-10, Vol.14 (1), p.206-206, Article 206
Description: Vitamin D insufficiency is associated with proteinuria and could be a risk factor for end-stage renal disease (ESRD). However, few studies have examined the significance of vitamin D insufficiency as a contributing factor for the development of ESRD in the Asian chronic kidney disease (CKD) population. Authors examined the relationship between vitamin D status and the staging of CKD using data from an outpatient clinic-based screening in 2,895 Thai CKD patients. Serum levels of 25-hydroxyvitamin D were analyzed according to CKD stages. Vitamin D deficiency and insufficiency were defined as a serum 25-hydroxyvitamin D concentration < 10 ng/mL and 10-30 ng/mL, respectively. The mean (SD) 25-hydroxyvitamin D levels were significantly lower according to severity of renal impairment (CKD stage 3a: 27.84 ± 14.03 ng/mL, CKD stage 3b: 25.86 ± 11.14 ng/mL, CKD stage 4: 24.09 ± 11.65 and CKD stage 5: 20.82 ± 9.86 ng/mL, p<0.001). The prevalence of vitamin D deficiency/insufficiency was from CKD stage 3a, 3b, 4 to 5, 66.6%, 70.9%, 74.6%, and 84.7% (p<0.001). The odds ratio (95% CI) of vitamin D insufficiency/deficiency (serum 25-hydroxyvitamin D ≤ 30 ng/mL) and vitamin D deficiency (serum 25-hydroxyvitamin D < 10 ng/mL) for developing ESRD, after adjustment for age, gender, hemoglobin, serum albumin, calcium, phosphate and alkaline phosphatase were 2.19 (95% CI 1.07 to 4.48) and 16.76 (95% CI 4.89 to 57.49), respectively. This study demonstrates that 25-hydroxyvitamin D insufficiency and deficiency are more common and associated with the level of kidney function in the Thai CKD population especially advanced stage of CKD.
Publisher: England: BioMed Central Ltd
Language: English
Identifier: ISSN: 1471-2369
EISSN: 1471-2369
DOI: 10.1186/1471-2369-14-206
PMID: 24083392
Source: Open Access: PubMed Central
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Vitamin D insufficiency and deficiency with stages of chronic kidney disease in an Asian population

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