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Clonal Hematopoiesis: Crossroads of Aging, Cardiovascular Disease, and Cancer: JACC Review Topic of the Week

Journal of the American College of Cardiology, 2019-07, Vol.74 (4), p.567-577 [Peer Reviewed Journal]

Copyright © 2019 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. ;2019. American College of Cardiology Foundation ;ISSN: 0735-1097 ;EISSN: 1558-3597 ;DOI: 10.1016/j.jacc.2019.06.007 ;PMID: 31345432

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Title:
Clonal Hematopoiesis: Crossroads of Aging, Cardiovascular Disease, and Cancer: JACC Review Topic of the Week
Author: Libby, Peter ; Sidlow, Robert ; Lin, Amy E ; Gupta, Dipti ; Jones, Lee W ; Moslehi, Javid ; Zeiher, Andreas ; Jaiswal, Siddhartha ; Schulz, Christian ; Blankstein, Ron ; Bolton, Kelly L ; Steensma, David ; Levine, Ross L ; Ebert, Benjamin L
Subjects: Age ; Aging ; Algorithms ; Blood ; Bone marrow ; Cancer ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - genetics ; Cloning ; Congestive heart failure ; Coronary artery disease ; Deoxyribonucleic acid ; DNA ; DNA damage ; Genes ; Health risks ; Heart diseases ; Hematology ; Hematopoiesis ; Hematopoiesis - genetics ; Hematopoietic Stem Cells ; Hemopoiesis ; Humans ; Ischemia ; Leukemia ; Leukocytes ; Morphology ; Mutation ; Neoplasms - complications ; Neoplasms - genetics ; Oncology ; Phosphatase ; Progeny ; Proteins ; Risk analysis ; Risk Factors ; Risk management ; Stem cells ; Tumors
Is Part Of: Journal of the American College of Cardiology, 2019-07, Vol.74 (4), p.567-577
Description: A novel, common, and potent cardiovascular risk factor has recently emerged: clonal hematopoiesis of indeterminate potential (CHIP). CHIP arises from somatic mutations in hematopoietic stem cells that yield clonal progeny of mutant leukocytes in blood. Individuals with CHIP have a doubled risk of coronary heart disease and ischemic stroke, and worsened heart failure outcomes independent of traditional cardiovascular risk factors. The recognition of CHIP as a nontraditional risk factor challenges specialists in hematology/oncology and cardiovascular medicine alike. Should we screen for CHIP? If so, in whom? How should we assess cardiovascular risk in people with CHIP? How should we manage the excess cardiovascular risk in the absence of an evidence base? This review explains CHIP, explores the clinical quandaries, strives to provide reasonable recommendations for the multidisciplinary management of cardiovascular risk in individuals with CHIP, and highlights current knowledge gaps.
Publisher: United States: Elsevier Limited
Language: English
Identifier: ISSN: 0735-1097
EISSN: 1558-3597
DOI: 10.1016/j.jacc.2019.06.007
PMID: 31345432
Source: GFMER Free Medical Journals
MEDLINE
Alma/SFX Local Collection

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Clonal Hematopoiesis: Crossroads of Aging, Cardiovascular Disease, and Cancer: JACC Review Topic of the Week

Copyright © 2019 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. ;2019. American College of Cardiology Foundation ;ISSN: 0735-1097 ;EISSN: 1558-3597 ;DOI: 10.1016/j.jacc.2019.06.007 ;PMID: 31345432

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