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Risk Factor Variability and Cardiovascular Outcome: JACC Review Topic of the Week

Journal of the American College of Cardiology, 2019-05, Vol.73 (20), p.2596-2603 [Peer Reviewed Journal]

Copyright © 2019 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. ;2019. American College of Cardiology Foundation ;ISSN: 0735-1097 ;EISSN: 1558-3597 ;DOI: 10.1016/j.jacc.2019.02.063 ;PMID: 31118154

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Title:
Risk Factor Variability and Cardiovascular Outcome: JACC Review Topic of the Week
Author: Messerli, Franz H ; Hofstetter, Louis ; Rimoldi, Stefano F ; Rexhaj, Emrush ; Bangalore, Sripal
Subjects: Blood pressure ; Body weight ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - physiopathology ; Cause of Death - trends ; Cholesterol ; Congestive heart failure ; Coronary artery ; Coronary artery disease ; Dementia disorders ; End-stage renal disease ; Health risk assessment ; Health risks ; Heart attacks ; Heart rate ; Hemodynamics - physiology ; Humans ; Kidney diseases ; Morbidity - trends ; Mortality ; Periodicals as Topic ; Renal failure ; Risk analysis ; Risk Assessment - methods ; Risk Factors ; Survival Rate - trends ; United States - epidemiology ; Variability
Is Part Of: Journal of the American College of Cardiology, 2019-05, Vol.73 (20), p.2596-2603
Description: Until recently, intraindividual visit-to-visit variability of cardiovascular risk factors has been dismissed as random fluctuation. This simplistic concept was challenged by demonstrating that visit-to-visit blood pressure variability, independent of average blood pressure, was a powerful risk factor for stroke. Subsequently, variability of other cardiovascular risk factors such as cholesterol, glycemia, and body weight was documented to increase risk independent of their absolute values. Variability of these risk factors has been demonstrated to be a powerful predictor for all-cause and cardiovascular mortality, stroke, coronary artery disease, heart failure, end-stage renal disease, and dementia. With the notable exception of heart rate, cardiovascular risk factors must now be defined by 2 components: the magnitude and duration of sustained risk factor elevation and, equally important, the variability of the same risk factor over time.
Publisher: United States: Elsevier Limited
Language: English
Identifier: ISSN: 0735-1097
EISSN: 1558-3597
DOI: 10.1016/j.jacc.2019.02.063
PMID: 31118154
Source: GFMER Free Medical Journals
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Risk Factor Variability and Cardiovascular Outcome: JACC Review Topic of the Week

Copyright © 2019 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. ;2019. American College of Cardiology Foundation ;ISSN: 0735-1097 ;EISSN: 1558-3597 ;DOI: 10.1016/j.jacc.2019.02.063 ;PMID: 31118154

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