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HIV Infection Is Not Associated With Aortic Stiffness. Traditional Cardiovascular Risk Factors Are the Main Determinants—Cross-sectional Results of INI-ELSA-BRASIL

Journal of acquired immune deficiency syndromes (1999), 2018-05, Vol.78 (1), p.73-81 [Peer Reviewed Journal]

Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved. ;Copyright Lippincott Williams & Wilkins Ovid Technologies May 1, 2018 ;ISSN: 1525-4135 ;EISSN: 1944-7884 ;DOI: 10.1097/QAI.0000000000001646 ;PMID: 29624545

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Title:
HIV Infection Is Not Associated With Aortic Stiffness. Traditional Cardiovascular Risk Factors Are the Main Determinants—Cross-sectional Results of INI-ELSA-BRASIL
Author: Moreira, Rodrigo C ; Mill, José G ; Grinsztejn, Beatriz ; Veloso, Valdilea ; Fonseca, Maria de Jesus ; Griep, Rosane H ; Bensenor, Isabela ; Cardoso, Sandra W ; Lotufo, Paulo ; Chor, Dora ; Pacheco, Antonio G
Subjects: Adult ; Aged ; AIDS/HIV ; Aorta ; Arteries ; Arteriosclerosis ; Atherosclerosis ; Biomedical materials ; Brazil - epidemiology ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - complications ; Cardiovascular Diseases - epidemiology ; Cohort Studies ; Confidence intervals ; Cross-Sectional Studies ; Female ; Femur ; Follow-Up Studies ; Health risk assessment ; Health risks ; Hip ; HIV ; HIV Infections - complications ; HIV Infections - epidemiology ; Human immunodeficiency virus ; Humans ; Infections ; Male ; Middle Aged ; Pulse Wave Analysis ; Risk analysis ; Risk Factors ; Statistical analysis ; Stiffness ; Surgical implants ; Vascular Stiffness ; Wave velocity
Is Part Of: Journal of acquired immune deficiency syndromes (1999), 2018-05, Vol.78 (1), p.73-81
Description: INTRODUCTION:Aortic stiffness measured by carotid-femoral pulse wave velocity (cf-PWV) is a marker of subclinical atherosclerosis. We propose to assess whether HIV infection is associated with arterial stiffness and their determinants in HIV-infected subjects. METHODS:We compared data from an HIV cohort (644 patients, HIV+) in Rio de Janeiro with 2 groups105 HIV-negative (HIV−) individuals and 14,873 participants of the ELSA-Brasil study. We used multivariable linear regression to investigate factors associated with cf-PWV and whether HIV was independently associated with aortic stiffness and propensity score weighting to control for imbalances between groups. RESULTS:From 15,860 participants, cf-PWV was obtained in 15,622 (98.5%). Median age was 51 (interquartile range 45–58), 44.41 (35.73, 54.72), and 43.60 (36.01, 50.79) years (P < 0.001), and median cf-PWV (m/s; interquartile range) was 9.0 (8.10, 10.20), 8.70 (7.90, 10.20), and 8.48 (7.66, 9.40) for ELSA-Brasil, HIV− and HIV+, respectively (P < 0.001). In the final weighted multivariable models, HIV group was not associated with cf-PWV when compared either with ELSA-Brasil [β = −0.05; 95% confidence interval (CI) = −0.23; P = 0.12; P = 0.52] or with the HIV- groups (β = 0.10; 95% CI = −0.10; 0, 31; P = 0.32). Traditional risk factors were associated with higher cf-PWV levels in the HIV+ group, particularly waist-to-hip ratio (β = 0.20; 95% CI = 0.10; 0.30; P < 0.001, result per one SD change). CONCLUSIONS:HIV infection was not associated with higher aortic stiffness according to our study. In HIV-infected subjects, the stiffness of large arteries is mainly associated with traditional risk factors and not to the HIV infection per se.
Language: English
Identifier: ISSN: 1525-4135
EISSN: 1944-7884
DOI: 10.1097/QAI.0000000000001646
PMID: 29624545
Source: MEDLINE
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HIV Infection Is Not Associated With Aortic Stiffness. Traditional Cardiovascular Risk Factors Are the Main Determinants—Cross-sectional Results of INI-ELSA-BRASIL

Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved. ;Copyright Lippincott Williams & Wilkins Ovid Technologies May 1, 2018 ;ISSN: 1525-4135 ;EISSN: 1944-7884 ;DOI: 10.1097/QAI.0000000000001646 ;PMID: 29624545

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