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The relationship between 25-hydroxyvitamin D concentration in early pregnancy and pregnancy outcomes in a large, prospective cohort

British journal of nutrition, 2016-10, Vol.116 (8), p.1409-1415 [Peer Reviewed Journal]

Copyright © The Authors 2016 ;ISSN: 0007-1145 ;ISSN: 1475-2662 ;EISSN: 1475-2662 ;DOI: 10.1017/S0007114516003202 ;PMID: 27753425

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Title:
The relationship between 25-hydroxyvitamin D concentration in early pregnancy and pregnancy outcomes in a large, prospective cohort
Author: Boyle, Veronica T. ; Thorstensen, Eric B. ; Mourath, David ; Jones, M. Beatrix ; McCowan, Lesley M. E. ; Kenny, Louise C. ; Baker, Philip N.
Subjects: 25-Hydroxyvitamin D 2 - blood ; Biomarkers - blood ; Calcifediol - blood ; Cohort Studies ; Diabetes, Gestational - epidemiology ; Diabetes, Gestational - ethnology ; Diabetes, Gestational - etiology ; Dietary Surveys and Nutritional Epidemiology ; Female ; Fetal Growth Retardation - epidemiology ; Fetal Growth Retardation - ethnology ; Fetal Growth Retardation - etiology ; Humans ; Incidence ; Maternal Nutritional Physiological Phenomena - ethnology ; New Zealand - epidemiology ; Nutrition research ; Nutritional Status - ethnology ; Pre-Eclampsia - epidemiology ; Pre-Eclampsia - ethnology ; Pre-Eclampsia - etiology ; Pregnancy ; Pregnancy complications ; Pregnancy Complications - blood ; Pregnancy Complications - ethnology ; Pregnancy Complications - physiopathology ; Pregnancy Outcome - ethnology ; Pregnancy Trimester, Second ; Premature Birth - epidemiology ; Premature Birth - ethnology ; Premature Birth - etiology ; Prevalence ; Prospective Studies ; Risk ; Severity of Illness Index ; Vitamin D ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - ethnology ; Vitamin D Deficiency - physiopathology ; Vitamin deficiency
Is Part Of: British journal of nutrition, 2016-10, Vol.116 (8), p.1409-1415
Description: Vitamin D insufficiency and deficiency have been associated with an increased risk of adverse pregnancy outcomes. Controversy remains as findings have been inconsistent between disparate populations. The aim of this study was to investigate the relationship between vitamin D status and pregnancy outcomes in a large, prospective pregnancy cohort. 25-Hydroxyvitamin D concentration was analysed in serum samples collected at 15 weeks of gestation from 1710 New Zealand women participating in a large, observational study. Associations between vitamin D status and pre-eclampsia, preterm birth, small for gestational age (SGA) and gestational diabetes were investigated. The mean 25-hydroxyvitamin D concentration was 72·9 nmol/l. In all, 23 % had 25-hydroxyvitamin D concentrations <50 nmol/l, and 5 % of participants had concentrations <25 nmol/l. Women with 25-hydroxyvitamin D concentrations <75 nmol/l at 15 weeks of gestation were more likely to develop gestational diabetes mellitus than those with concentrations >75 nmol/l (OR 2·3; 95 % CI 1·1, 5·1). However, this effect was not significant when adjustments were made for BMI and ethnicity (OR 1·8; 95 % CI 0·8, 4·2). 25-Hydroxyvitamin D concentration at 15 weeks was not associated with development of pre-eclampsia, spontaneous preterm birth or SGA infants. Pregnancy complications were low in this largely vitamin D-replete population.
Publisher: Cambridge, UK: Cambridge University Press
Language: English
Identifier: ISSN: 0007-1145
ISSN: 1475-2662
EISSN: 1475-2662
DOI: 10.1017/S0007114516003202
PMID: 27753425
Source: MEDLINE
Alma/SFX Local Collection
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ProQuest Central

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The relationship between 25-hydroxyvitamin D concentration in early pregnancy and pregnancy outcomes in a large, prospective cohort

Copyright © The Authors 2016 ;ISSN: 0007-1145 ;ISSN: 1475-2662 ;EISSN: 1475-2662 ;DOI: 10.1017/S0007114516003202 ;PMID: 27753425

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