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Selenium and Coenzyme Q10 Intervention Prevents Telomere Attrition, with Association to Reduced Cardiovascular Mortality—Sub-Study of a Randomized Clinical Trial

Nutrients, 2022-08, Vol.14 (16), p.3346 [Peer Reviewed Journal]

2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;info:eu-repo/semantics/openAccess ;2022 by the authors. 2022 ;ISSN: 2072-6643 ;EISSN: 2072-6643 ;DOI: 10.3390/nu14163346 ;PMID: 36014852

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  • Title:
    Selenium and Coenzyme Q10 Intervention Prevents Telomere Attrition, with Association to Reduced Cardiovascular Mortality—Sub-Study of a Randomized Clinical Trial
  • Author: Opstad, Trine Baur ; Alexander, Jan ; Aaseth, Jan O. ; Larsson, Anders ; Seljeflot, Ingebjørg ; Alehagen, Urban
  • Subjects: Aging ; Antioxidants ; Cardiovascular disease ; Cardiovascular diseases ; Clinical trials ; Coenzyme Q10 ; Health services ; Leukocytes ; Mortality ; Oxidative stress ; Placebos ; Selenium ; Senescence ; Telomerase ; telomere ; Telomeres ; ubiquinone
  • Is Part Of: Nutrients, 2022-08, Vol.14 (16), p.3346
  • Description: Short telomeres have been associated with ageing and cardiovascular disease. The influence on leukocyte telomere length (LTL) of long-term intervention with combined selenium and coenzyme Q10 is unknown. Our aim was to determine whether 42 months of selenium and coenzyme Q10 supplementation prevented telomere attrition and further cardiovascular mortality. The investigation is an explorative sub-study of a double-blind, placebo-controlled, randomized trial. Swedish citizens low in selenium (n = 118), aged 70–80 years, were included. Intervention time was 4 years, with 10 years’ follow-up time. LTL was relatively quantified with PCR at baseline and after 42 months. At baseline, LTL (SD) was 0.954 (0.260) in the active treatment group and 1.018 (0.317) in the placebo group (p = 0.23). At 42 months, less shortening of LTL was observed after active treatment compared with placebo (+0.019 vs. −0.129, respectively, p = 0.02), with a significant difference in change basing the analysis on individual changes in LTL (p < 0.001). Subjects suffering future death presented with significantly shorter LTL at 42 months than survivors [0.791 (0.190) vs. 0.941 (0.279), p = 0.01], with a significant difference in change of LTL according to cardiovascular mortality and survival (p = 0.03). To conclude, preservation of LTL after selenium and coenzyme Q10 supplementation associated with reduced cardiovascular mortality.
  • Publisher: Basel: MDPI AG
  • Language: English;Norwegian
  • Identifier: ISSN: 2072-6643
    EISSN: 2072-6643
    DOI: 10.3390/nu14163346
    PMID: 36014852
  • Source: Open Access: DOAJ Directory of Open Access Journals
    Open Access: PubMed Central
    Geneva Foundation Free Medical Journals at publisher websites
    AUTh Library subscriptions: ProQuest Central
    NORA Norwegian Open Research Archives
    ROAD: Directory of Open Access Scholarly Resources
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