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In vivo observation and biophysical interpretation of time-dependent diffusion in human white matter

NeuroImage (Orlando, Fla.), 2016-04, Vol.129, p.414-427 [Peer Reviewed Journal]

2016 Elsevier Inc. ;Copyright © 2016 Elsevier Inc. All rights reserved. ;Copyright Elsevier Limited Apr 1, 2016 ;ISSN: 1053-8119 ;EISSN: 1095-9572 ;DOI: 10.1016/j.neuroimage.2016.01.018 ;PMID: 26804782

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  • Title:
    In vivo observation and biophysical interpretation of time-dependent diffusion in human white matter
  • Author: Fieremans, Els ; Burcaw, Lauren M. ; Lee, Hong-Hsi ; Lemberskiy, Gregory ; Veraart, Jelle ; Novikov, Dmitry S.
  • Subjects: Adult ; Brain - ultrastructure ; Brain Mapping - methods ; Diffusion ; Diffusion MRI ; Diffusion Tensor Imaging ; Female ; Hindered diffusion ; Humans ; Image Processing, Computer-Assisted ; Male ; STEAM sequence ; Time-dependent diffusion ; White matter ; White Matter - ultrastructure
  • Is Part Of: NeuroImage (Orlando, Fla.), 2016-04, Vol.129, p.414-427
  • Description: The presence of micrometer-level restrictions leads to a decrease of diffusion coefficient with diffusion time. Here we investigate this effect in human white matter in vivo. We focus on a broad range of diffusion times, up to 600ms, covering diffusion length scales up to about 30 μm. We perform stimulated echo diffusion tensor imaging on 5 healthy volunteers and observe a relatively weak time-dependence in diffusion transverse to major fiber tracts. Remarkably, we also find notable time-dependence in the longitudinal direction. Comparing models of diffusion in ordered, confined and disordered media, we argue that the time-dependence in both directions can arise due to structural disorder, such as axonal beads in the longitudinal direction, and the random packing geometry of fibers within a bundle in the transverse direction. These time-dependent effects extend beyond a simple picture of Gaussian compartments, and may lead to novel markers that are specific to neuronal fiber geometry at the micrometer scale. •We measure time-dependent DTI (55 ms – 600 ms) in vivo in human white matter.•Pronounced longitudinal and weaker transverse time-dependent diffusion is observed.•Longitudinal time-dependence is attributed to axonal varicosities.•Transverse time-dependence is attributed to the random axon packing geometry.•Varying diffusion time may provide a novel microstructural contrast.
  • Publisher: United States: Elsevier Inc
  • Language: English
  • Identifier: ISSN: 1053-8119
    EISSN: 1095-9572
    DOI: 10.1016/j.neuroimage.2016.01.018
    PMID: 26804782
  • Source: ProQuest One Psychology
    MEDLINE
    Alma/SFX Local Collection
    ProQuest Central
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