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CD103+ lung dendritic cells (LDCs) induce stronger Th1/Th17 immunity to a bacterial lung infection than CD11bhi LDCs

Cellular & molecular immunology, 2018-04, Vol.15 (4), p.377-387 [Peer Reviewed Journal]

Copyright Nature Publishing Group Apr 2018 ;CSI and USTC 2017 ;ISSN: 1672-7681 ;EISSN: 2042-0226 ;DOI: 10.1038/cmi.2016.68 ;PMID: 28194020

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  • Title:
    CD103+ lung dendritic cells (LDCs) induce stronger Th1/Th17 immunity to a bacterial lung infection than CD11bhi LDCs
  • Author: Shekhar, Sudhanshu ; Peng, Ying ; Wang, Shuhe ; Yang, Xi
  • Subjects: Adoptive transfer ; Apoptosis ; Bacterial infections ; CD103 antigen ; CD11b antigen ; CD4 antigen ; CD40 antigen ; CD80 antigen ; CD86 antigen ; Cell culture ; Chlamydia ; Costimulator ; Dendritic cells ; Helper cells ; Infections ; Interleukin 10 ; Interleukin 12 ; Interleukin 17 ; Interleukin 23 ; Interleukin 6 ; Lungs ; Lymphocytes T ; PD-L1 protein ; γ-Interferon
  • Is Part Of: Cellular & molecular immunology, 2018-04, Vol.15 (4), p.377-387
  • Description: Recent studies suggest differential roles for CD103+ and CD11bhi lung dendritic cells (LDCs) in host defense against viral and bacterial infections. In this study, we examined the contribution of these LDC subsets in protective immunity to chlamydial lung infection using a Chlamydia muridarum mouse infection model. We found that CD103+ LDCs showed higher expression of costimulatory molecules (CD40, CD80 and CD86) and increased production of cytokines (IL-12p70, IL-10, IL-23 and IL-6) compared with CD11bhi LDCs, but the expression of programmed death-ligand 1 (PD-L1) was similar between the two subsets. More importantly, we found, in adoptive transfer experiments, that the mice receiving CD103+ LDCs from Chlamydia-infected mice exhibited better protection than the recipients of CD11bhi LDCs, which was associated with more robust Th1/Th17 cytokine responses. In addition, in vitro experiments showed that CD103+ LDCs induced stronger IFN-γ and IL-17 responses, when cocutured with chlamydial antigen-primed CD4+ T cells, than CD11bhi LDCs. Furthermore, the blockade of PD1 in the culture of CD4+ T cells with either CD103+ or CD11bhi LDCs enhanced production of IFN-γ and IL-17. In conclusion, our data provide direct evidence that CD103+ LDCs are more potent in promoting Th1/Th17 immunity to chlamydial lung infection than CD11bhi LDCs.
  • Publisher: London: Nature Publishing Group
  • Language: English
  • Identifier: ISSN: 1672-7681
    EISSN: 2042-0226
    DOI: 10.1038/cmi.2016.68
    PMID: 28194020
  • Source: GFMER Free Medical Journals
    PubMed Central
    ProQuest Central
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