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Application of Fullerenes as Photosensitizers for Antimicrobial Photodynamic Inactivation: A Review

Frontiers in microbiology, 2022-07, Vol.13, p.957698-957698 [Peer Reviewed Journal]

Copyright © 2022 Hou, Shi, Wu, Mo, Shen, Zhang and Zhu. 2022 Hou, Shi, Wu, Mo, Shen, Zhang and Zhu ;ISSN: 1664-302X ;EISSN: 1664-302X ;DOI: 10.3389/fmicb.2022.957698 ;PMID: 35910649

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  • Title:
    Application of Fullerenes as Photosensitizers for Antimicrobial Photodynamic Inactivation: A Review
  • Author: Hou, Wenjia ; Shi, Guorui ; Wu, Songze ; Mo, Jiayi ; Shen, Lan ; Zhang, Xiuqiang ; Zhu, Yabin
  • Subjects: antibacterial ; antimicrobial photodynamic inactivation ; fullerene derivatives ; functionalization ; Microbiology ; multidrug resistance ; photosensitizers
  • Is Part Of: Frontiers in microbiology, 2022-07, Vol.13, p.957698-957698
  • Description: Antimicrobial photodynamic inactivation (aPDI) is a newly emerged treatment approach that can effectively address the issue of multidrug resistance resulting from the overuse of antibiotics. Fullerenes can be used as promising photosensitizers (PSs) for aPDI due to the advantages of high triplet state yields, good photostability, wide antibacterial spectrum, and permissibility of versatile functionalization. This review introduces the photodynamic activities of fullerenes and the up-to-date understanding of the antibacterial mechanisms of fullerene-based aPDI. The most recent works on the functionalization of fullerenes and the application of fullerene derivatives as PSs for aPDI are also summarized. Finally, certain remaining challenges are emphasized to provide guidance on future research directions for achieving clinical application of fullerene-based aPDI.
  • Publisher: Frontiers Media S.A
  • Language: English
  • Identifier: ISSN: 1664-302X
    EISSN: 1664-302X
    DOI: 10.3389/fmicb.2022.957698
    PMID: 35910649
  • Source: GFMER Free Medical Journals
    PubMed Central
    ROAD: Directory of Open Access Scholarly Resources
    DOAJ Directory of Open Access Journals

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