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Clinical Features of 85 Fatal Cases of COVID-19 from Wuhan. A Retrospective Observational Study

American journal of respiratory and critical care medicine, 2020-06, Vol.201 (11), p.1372-1379 [Peer Reviewed Journal]

Copyright American Thoracic Society Jun 1, 2020 ;Copyright © 2020 by the American Thoracic Society 2020 ;ISSN: 1073-449X ;EISSN: 1535-4970 ;DOI: 10.1164/rccm.202003-0543oc ;PMID: 32242738

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Title:
Clinical Features of 85 Fatal Cases of COVID-19 from Wuhan. A Retrospective Observational Study
Author: Du, Yingzhen ; Tu, Lei ; Zhu, Pingjun ; Mu, Mi ; Wang, Runsheng ; Yang, Pengcheng ; Wang, Xi ; Hu, Chao ; Ping, Rongyu ; Hu, Peng ; Li, Tianzhi ; Cao, Feng ; Chang, Christopher ; Hu, Qinyong ; Jin, Yang ; Xu, Guogang
Subjects: Adolescent ; Adult ; Aged ; Aged, 80 and over ; Betacoronavirus ; China - epidemiology ; Collections ; Comorbidity ; Coronary Disease - epidemiology ; Coronavirus Infections - mortality ; COVID-19 ; Diabetes Mellitus - epidemiology ; Female ; Humans ; Hypertension - epidemiology ; Male ; Medical imaging ; Middle Aged ; Multiple Organ Failure - virology ; Original ; Pandemics ; Pneumonia, Viral - mortality ; Retrospective Studies ; Risk factors ; SARS-CoV-2 ; Tomography, X-Ray Computed ; Young Adult
Is Part Of: American journal of respiratory and critical care medicine, 2020-06, Vol.201 (11), p.1372-1379
Description: The global death toll from coronavirus disease (COVID-19) virus as of May 12, 2020, exceeds 286,000. The risk factors for death were attributed to advanced age and comorbidities but have not been accurately defined. To report the clinical features of 85 fatal cases of COVID-19 in two hospitals in Wuhan. Medical records were collected of 85 fatal cases of COVID-19 between January 9, 2020, and February 15, 2020. Information recorded included medical history, exposure history, comorbidities, symptoms, signs, laboratory findings, computed tomographic scans, and clinical management. The median age of the patients was 65.8 years, and 72.9% were male. Common symptoms were fever (78 [91.8%]), shortness of breath (50 [58.8%]), fatigue (50 [58.8%]), and dyspnea (60 [70.6%]). Hypertension, diabetes, and coronary heart disease were the most common comorbidities. Notably, 81.2% of patients had very low eosinophil counts on admission. Complications included respiratory failure (80 [94.1%]), shock (69 [81.2%]), acute respiratory distress syndrome (63 [74.1%]), and arrhythmia (51 [60%]), among others. Most patients received antibiotic (77 [90.6%]), antiviral (78 [91.8%]), and glucocorticoid (65 [76.5%]) treatments. A total of 38 (44.7%) and 33 (38.8%) patients received intravenous immunoglobulin and IFN-α2b, respectively. In this depictive study of 85 fatal cases of COVID-19, most cases were males aged over 50 years with noncommunicable chronic diseases. The majority of the patients died of multiple organ failure. Early onset of shortness of breath may be used as an observational symptom for COVID-19 exacerbations. Eosinophilopenia may indicate a poor prognosis. A combination of antimicrobial drugs did not offer considerable benefit to the outcome of this group of patients.
Publisher: United States: American Thoracic Society
Language: English
Identifier: ISSN: 1073-449X
EISSN: 1535-4970
DOI: 10.1164/rccm.202003-0543oc
PMID: 32242738
Source: Geneva Foundation Free Medical Journals at publisher websites
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Clinical Features of 85 Fatal Cases of COVID-19 from Wuhan. A Retrospective Observational Study

Copyright American Thoracic Society Jun 1, 2020 ;Copyright © 2020 by the American Thoracic Society 2020 ;ISSN: 1073-449X ;EISSN: 1535-4970 ;DOI: 10.1164/rccm.202003-0543oc ;PMID: 32242738

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