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Association between Common Genetic Variants and Polycystic Ovary Syndrome Risk in a Chinese Han Population

Journal of clinical research in pediatric endocrinology, 2016-12, Vol.8 (4), p.405-410 [Peer Reviewed Journal]

COPYRIGHT 2016 Galenos Yayinevi Tic. Ltd. ;Copyright Galenos Yayinevi Dec 2016 ;Journal of Clinical Research in Pediatric Endocrinology, Published by Galenos Publishing. 2016 ;ISSN: 1308-5727 ;EISSN: 1308-5735 ;DOI: 10.4274/jcrpe.2784 ;PMID: 27217259

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Title:
Association between Common Genetic Variants and Polycystic Ovary Syndrome Risk in a Chinese Han Population
Author: Sun, Ying ; Yuan, Yi ; Yang, Hua ; Li, Jingjie ; Feng, Tian ; Ouyang, Yongri ; Jin, Tianbo ; Liu, Ming
Subjects: Adult ; Alleles ; Analysis ; Asian Continental Ancestry Group - genetics ; Case-Control Studies ; China ; Female ; Gene Frequency ; Genetic aspects ; Genetic Predisposition to Disease - ethnology ; Genetic Predisposition to Disease - genetics ; Genome-Wide Association Study - methods ; Genotype ; Health aspects ; Health risk assessment ; Humans ; Linkage Disequilibrium ; Original ; Oxidoreductases Acting on Sulfur Group Donors - genetics ; Polycystic Ovary Syndrome - ethnology ; Polycystic Ovary Syndrome - genetics ; Polymorphism, Single Nucleotide ; rab5 GTP-Binding Proteins - genetics ; Risk Factors ; Single nucleotide polymorphisms ; Stein-Leventhal syndrome ; Women ; Young Adult
Is Part Of: Journal of clinical research in pediatric endocrinology, 2016-12, Vol.8 (4), p.405-410
Description: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies affecting 5-7% of reproductive age women worldwide. The aim of our study was to explore the PCOS-related single nucleotide polymorphism (SNP) associations between common genetic variants and PCOS risk in a Han Chinese women population. In this case-control study, 285 Chinese Han women aged 28.50±6.858 years with PCOS and 299 controls of a mean age of 32.66±7.018 years were compared. We selected recently published genome-wide association studies (GWAS) which identified several genetic loci in PCOS. All the SNPs were genotyped by Sequenom Mass-ARRAY technology. Associations between the gene and the risk of PCOS were tested using various genetic models by Statistical Package for the Social Sciences and Plink. We found that rs705702 in the RAB5B/SUOX was associated with PCOS (odds ratio=1.42; 95% confidence interval=1.08-1.87, p=0.011) and increased the PCOS risk. The genotypic model analysis also showed that rs705702 was associated with PCOS risk. Our results suggest that SNPs rs705702 in gene RAB5B/SUOX was associated with PCOS in Han Chinese women.
Publisher: Turkey: Galenos Yayinevi Tic. Ltd
Language: English;Turkish
Identifier: ISSN: 1308-5727
EISSN: 1308-5735
DOI: 10.4274/jcrpe.2784
PMID: 27217259
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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Association between Common Genetic Variants and Polycystic Ovary Syndrome Risk in a Chinese Han Population

COPYRIGHT 2016 Galenos Yayinevi Tic. Ltd. ;Copyright Galenos Yayinevi Dec 2016 ;Journal of Clinical Research in Pediatric Endocrinology, Published by Galenos Publishing. 2016 ;ISSN: 1308-5727 ;EISSN: 1308-5735 ;DOI: 10.4274/jcrpe.2784 ;PMID: 27217259

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