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Genomic landscape of lung adenocarcinoma in East Asians

Nature genetics, 2020-02, Vol.52 (2), p.177-186 [Peer Reviewed Journal]

COPYRIGHT 2020 Nature Publishing Group ;COPYRIGHT 2020 Nature Publishing Group ;ISSN: 1061-4036 ;EISSN: 1546-1718 ;DOI: 10.1038/s41588-019-0569-6 ;PMID: 32015526

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Title:
Genomic landscape of lung adenocarcinoma in East Asians
Author: Chen, Jianbin ; Yang, Hechuan ; Teo, Audrey Su Min ; Amer, Lidyana Bte ; Sherbaf, Faranak Ghazi ; Tan, Chu Quan ; Alvarez, Jacob Josiah Santiago ; Lu, Bingxin ; Lim, Jia Qi ; Takano, Angela ; Nahar, Rahul ; Lee, Yin Yeng ; Phua, Cheryl Zi Jin ; Chua, Khi Pin ; Suteja, Lisda ; Chen, Pauline Jieqi ; Chang, Mei Mei ; Koh, Tina Puay Theng ; Ong, Boon-Hean ; Anantham, Devanand ; Hsu, Anne Ann Ling ; Gogna, Apoorva ; Too, Chow Wei ; Aung, Zaw Win ; Lee, Yi Fei ; Wang, Lanying ; Lim, Tony Kiat Hon ; Wilm, Andreas ; Choi, Poh Sum ; Ng, Poh Yong ; Toh, Chee Keong ; Lim, Wan-Teck ; Ma, Siming ; Lim, Bing ; Liu, Jin ; Tam, Wai Leong ; Skanderup, Anders Jacobsen ; Yeong, Joe Poh Sheng ; Tan, Eng-Huat ; Creasy, Caretha L ; Tan, Daniel Shao Weng ; Hillmer, Axel M ; Zhai, Weiwei
Subjects: Adenocarcinoma ; Adenocarcinoma of Lung - etiology ; Adenocarcinoma of Lung - genetics ; Adenocarcinoma of Lung - mortality ; Adenocarcinoma of Lung - therapy ; Aged ; Asian Continental Ancestry Group - genetics ; Cancer ; Cohort Studies ; Comparative analysis ; DNA Copy Number Variations ; ErbB Receptors - genetics ; Exome ; Female ; Gene Expression Profiling ; Genes ; Genetic aspects ; Genomes ; Genomics ; Health aspects ; Humans ; Immunotherapy ; Lung cancer ; Lung Neoplasms - etiology ; Lung Neoplasms - genetics ; Lung Neoplasms - mortality ; Lung Neoplasms - therapy ; Male ; Medical colleges ; Middle Aged ; Mutation ; Proto-Oncogene Proteins p21(ras) - genetics ; Singapore ; Smokers ; Tumor Suppressor Protein p53 - genetics
Is Part Of: Nature genetics, 2020-02, Vol.52 (2), p.177-186
Description: Lung cancer is the world's leading cause of cancer death and shows strong ancestry disparities. By sequencing and assembling a large genomic and transcriptomic dataset of lung adenocarcinoma (LUAD) in individuals of East Asian ancestry (EAS; n = 305), we found that East Asian LUADs had more stable genomes characterized by fewer mutations and fewer copy number alterations than LUADs from individuals of European ancestry. This difference is much stronger in smokers as compared to nonsmokers. Transcriptomic clustering identified a new EAS-specific LUAD subgroup with a less complex genomic profile and upregulated immune-related genes, allowing the possibility of immunotherapy-based approaches. Integrative analysis across clinical and molecular features showed the importance of molecular phenotypes in patient prognostic stratification. EAS LUADs had better prediction accuracy than those of European ancestry, potentially due to their less complex genomic architecture. This study elucidated a comprehensive genomic landscape of EAS LUADs and highlighted important ancestry differences between the two cohorts.
Publisher: United States: Nature Publishing Group
Language: English
Identifier: ISSN: 1061-4036
EISSN: 1546-1718
DOI: 10.1038/s41588-019-0569-6
PMID: 32015526
Source: GFMER Free Medical Journals
MEDLINE
ProQuest Central

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Genomic landscape of lung adenocarcinoma in East Asians

COPYRIGHT 2020 Nature Publishing Group ;COPYRIGHT 2020 Nature Publishing Group ;ISSN: 1061-4036 ;EISSN: 1546-1718 ;DOI: 10.1038/s41588-019-0569-6 ;PMID: 32015526

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