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Antibody-secreting plasma cells persist for decades in human intestine

The Journal of experimental medicine, 2017-02, Vol.214 (2), p.309-317 [Peer Reviewed Journal]

2017 Landsverk et al. ;Copyright Rockefeller University Press Feb 2017 ;info:eu-repo/semantics/openAccess ;2017 Landsverk et al. 2017 ;ISSN: 0022-1007 ;ISSN: 1540-9538 ;EISSN: 1540-9538 ;DOI: 10.1084/jem.20161590 ;PMID: 28104812

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Title:
Antibody-secreting plasma cells persist for decades in human intestine
Author: Landsverk, Ole J B ; Snir, Omri ; Casado, Raquel Bartolomé ; Richter, Lisa ; Mold, Jeff E ; Réu, Pedro ; Horneland, Rune ; Paulsen, Vemund ; Yaqub, Sheraz ; Aandahl, Einar Martin ; Øyen, Ole M ; Thorarensen, Hildur Sif ; Salehpour, Mehran ; Possnert, Göran ; Frisén, Jonas ; Sollid, Ludvig M ; Baekkevold, Espen S ; Jahnsen, Frode L
Subjects: Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antibodies ; Antibody response ; Antibody-Producing Cells - immunology ; Antigens ; Antigens, CD19 - analysis ; Bone marrow ; Carbon 14 ; CD19 antigen ; CD45 antigen ; Child ; Deoxyribonucleic acid ; DNA ; Dynamic tests ; Female ; Fysik med inriktning mot jonfysik ; Humans ; Immunity ; Intestines - immunology ; Leukocyte Common Antigens - analysis ; Male ; Medicin och hälsovetenskap ; Middle Aged ; Physics with specialization in Ion Physics ; Plasma ; Plasma cells ; Plasma Cells - immunology ; Rotavirus ; Small intestine ; Small intestine transplantation ; Transplants ; Vaccination
Is Part Of: The Journal of experimental medicine, 2017-02, Vol.214 (2), p.309-317
Description: Plasma cells (PCs) produce antibodies that mediate immunity after infection or vaccination. In contrast to PCs in the bone marrow, PCs in the gut have been considered short lived. In this study, we studied PC dynamics in the human small intestine by cell-turnover analysis in organ transplants and by retrospective cell birth dating measuring carbon-14 in genomic DNA. We identified three distinct PC subsets: a CD19 PC subset was dynamically exchanged, whereas of two CD19 PC subsets, CD45 PCs exhibited little and CD45 PCs no replacement and had a median age of 11 and 22 yr, respectively. Accumulation of CD45 PCs during ageing and the presence of rotavirus-specific clones entirely within the CD19 PC subsets support selection and maintenance of protective PCs for life in human intestine.
Publisher: United States: Rockefeller University Press
Language: English;Norwegian
Identifier: ISSN: 0022-1007
ISSN: 1540-9538
EISSN: 1540-9538
DOI: 10.1084/jem.20161590
PMID: 28104812
Source: GFMER Free Medical Journals
MEDLINE
NORA Norwegian Open Research Archives
PubMed Central
SWEPUB Freely available online

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Antibody-secreting plasma cells persist for decades in human intestine

2017 Landsverk et al. ;Copyright Rockefeller University Press Feb 2017 ;info:eu-repo/semantics/openAccess ;2017 Landsverk et al. 2017 ;ISSN: 0022-1007 ;ISSN: 1540-9538 ;EISSN: 1540-9538 ;DOI: 10.1084/jem.20161590 ;PMID: 28104812

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