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Disease-driving CD4+ T cell clonotypes persist for decades in celiac disease

The Journal of clinical investigation, 2018-06, Vol.128 (6), p.2642-2650 [Peer Reviewed Journal]

info:eu-repo/semantics/openAccess ;Copyright © 2018, American Society for Clinical Investigation 2018 American Society for Clinical Investigation ;ISSN: 0021-9738 ;EISSN: 1558-8238 ;DOI: 10.1172/JCI98819 ;PMID: 29757191

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  • Title:
    Disease-driving CD4+ T cell clonotypes persist for decades in celiac disease
  • Author: Risnes, Louise F ; Christophersen, Asbjørn ; Dahal-Koirala, Shiva ; Neumann, Ralf S ; Sandve, Geir K ; Sarna, Vikas K ; Lundin, Knut Ea ; Qiao, Shuo-Wang ; Sollid, Ludvig M
  • Is Part Of: The Journal of clinical investigation, 2018-06, Vol.128 (6), p.2642-2650
  • Description: Little is known about the repertoire dynamics and persistence of pathogenic T cells in HLA-associated disorders. In celiac disease, a disorder with a strong association with certain HLA-DQ allotypes, presumed pathogenic T cells can be visualized and isolated with HLA-DQ:gluten tetramers, thereby enabling further characterization. Single and bulk populations of HLA-DQ:gluten tetramer-sorted CD4+ T cells were analyzed by high-throughput DNA sequencing of rearranged TCR-α and -β genes. Blood and gut biopsy samples from 21 celiac disease patients, taken at various stages of disease and in intervals of weeks to decades apart, were examined. Persistence of the same clonotypes was seen in both compartments over decades, with up to 53% overlap between samples obtained 16 to 28 years apart. Further, we observed that the recall response following oral gluten challenge was dominated by preexisting CD4+ T cell clonotypes. Public features were frequent among gluten-specific T cells, as 10% of TCR-α, TCR-β, or paired TCR-αβ amino acid sequences of total 1813 TCRs generated from 17 patients were observed in 2 or more patients. In established celiac disease, the T cell clonotypes that recognize gluten are persistent for decades, making up fixed repertoires that prevalently exhibit public features. These T cells represent an attractive therapeutic target.
  • Publisher: United States: Stanford University
  • Language: English;Norwegian
  • Identifier: ISSN: 0021-9738
    EISSN: 1558-8238
    DOI: 10.1172/JCI98819
    PMID: 29757191
  • Source: Geneva Foundation Free Medical Journals at publisher websites
    NORA Norwegian Open Research Archives
    PubMed Central
    Alma/SFX Local Collection
    ProQuest Central
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