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Fluorescent cell-based sensing approaches for toxicity testing

Analytical and bioanalytical chemistry, 2010-09, Vol.398 (1), p.181-191 [Peer Reviewed Journal]

Springer-Verlag 2010 ;COPYRIGHT 2010 Springer ;ISSN: 1618-2642 ;ISSN: 1618-2650 ;EISSN: 1618-2650 ;DOI: 10.1007/s00216-010-3651-6 ;PMID: 20354845

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Title:
Fluorescent cell-based sensing approaches for toxicity testing
Author: Fritzsche, Michael ; Mandenius, Carl-Fredrik
Subjects: Alternative methods ; Analysis ; Analytical Chemistry ; Animals ; B cells ; Biochemistry ; Biosensing Techniques - methods ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Cytotoxicity ; Detection ; Fluorescence ; Food Science ; Humans ; In-vitro assays ; In-vitro testing ; Integrity ; Labelling ; Laboratory Medicine ; Mathematical analysis ; Monitoring/Environmental Analysis ; NATURAL SCIENCES ; NATURVETENSKAP ; Pathogens ; Pharmaceutical Preparations - analysis ; Pharmacology ; Pollutants ; Review ; Screening ; Toxicity testing ; Toxicity Tests
Is Part Of: Analytical and bioanalytical chemistry, 2010-09, Vol.398 (1), p.181-191
Description: Fluorimetric cell-based sensing methods have attracted increasing interest in toxicity testing of pharmaceuticals, pathogens, environmental pollutants, and other chemicals. The objective of this review is to summarise the variety of approaches reported up to now and to present recent developments in this area. The different approaches are described in relation to their underlying mechanism and, especially, to the role of the fluorophore involved. The methods discussed include the use of fluorescent or fluorogenic indicators, fluorescence-based testing for membrane integrity, approaches based on fluorescence labelling, inducible fluorescent protein expression, and analysis of cellular autofluorescence. Several of these approaches have been shown to be advantageous in comparison with non-fluorescence methods and have potential in high-throughput screening, for example in drug discovery and safety pharmacology.
Publisher: Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag
Language: English
Identifier: ISSN: 1618-2642
ISSN: 1618-2650
EISSN: 1618-2650
DOI: 10.1007/s00216-010-3651-6
PMID: 20354845
Source: MEDLINE
Alma/SFX Local Collection

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Fluorescent cell-based sensing approaches for toxicity testing

Springer-Verlag 2010 ;COPYRIGHT 2010 Springer ;ISSN: 1618-2642 ;ISSN: 1618-2650 ;EISSN: 1618-2650 ;DOI: 10.1007/s00216-010-3651-6 ;PMID: 20354845

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