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Recurrent Implantation Failure-update overview on etiology, diagnosis, treatment and future directions

Reproductive biology and endocrinology, 2018-12, Vol.16 (1), p.121-121, Article 121 [Peer Reviewed Journal]

COPYRIGHT 2018 BioMed Central Ltd. ;Copyright © 2018. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s). 2018 ;ISSN: 1477-7827 ;EISSN: 1477-7827 ;DOI: 10.1186/s12958-018-0414-2 ;PMID: 30518389

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Title:
Recurrent Implantation Failure-update overview on etiology, diagnosis, treatment and future directions
Author: Bashiri, Asher ; Halper, Katherine Ida ; Orvieto, Raoul
Subjects: Age ; Autoantibodies ; Body mass index ; Chronic endometritis ; Embryo Implantation - physiology ; Embryo Transfer - methods ; Embryo transplantation ; Embryos ; Endometrial scratching ; Endometritis ; Endometritis - diagnosis ; Endometritis - etiology ; Endometritis - therapy ; Endometrium ; Etiology ; Female ; Fertilization in vitro ; Fertilization in Vitro - methods ; Genetic analysis ; Genetic screening ; Humans ; Immunology ; In vitro fertilization ; Infertility, Female - diagnosis ; Infertility, Female - etiology ; Infertility, Female - therapy ; IVIG ; Low molecular weight heparin ; Medical diagnosis ; Methods ; Patients ; Physiological aspects ; Polyps ; Pregnancy ; Preimplantation Diagnosis ; Preimplantation Genetic Screening- PGS ; Recurrence ; Recurrent implantation failure-RIF ; Reinforcement ; Reproductive technologies ; Review ; Risk Factors ; Smoking ; Sperm ; Treatment Failure ; Ultrasonic imaging ; Uterus
Is Part Of: Reproductive biology and endocrinology, 2018-12, Vol.16 (1), p.121-121, Article 121
Description: Recurrent implantation failure (RIF) refers to cases in which women have had three failed in vitro fertilization (IVF) attempts with good quality embryos. The definition should also take advanced maternal age and embryo stage into consideration. The failure of embryo implantation can be a consequence of uterine, male, or embryo factors, or the specific type of IVF protocol. These cases should be investigated to determine the most likely etiologies of the condition, as this is a complex problem with several variables. There are multiple risk factors for recurrent implantation failure including advanced maternal age, smoking status of both parents, elevated body mass index, and stress levels. Immunological factors such as cytokine levels and presence of specific autoantibodies should be examined, as well as any infectious organisms in the uterus leading to chronic endometritis. Uterine pathologies such as polyps and myomas as well as congenital anatomical anomalies should be ruled out. Sperm analysis, pre-implantation genetic screening and endometrial receptivity should be considered and evaluated, and IVF protocols should be tailored to specific patients or patient populations. Treatment approaches should be directed toward individual patient cases. In addition, we suggest considering a new initial step in approach to patients with RIF, individualized planned activities to activate the brain's reward system in attempt to improve immunological balance in the body.
Publisher: England: BioMed Central Ltd
Language: English
Identifier: ISSN: 1477-7827
EISSN: 1477-7827
DOI: 10.1186/s12958-018-0414-2
PMID: 30518389
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
Springer Nature OA/Free Journals
ROAD: Directory of Open Access Scholarly Resources
ProQuest Central
DOAJ Directory of Open Access Journals

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Recurrent Implantation Failure-update overview on etiology, diagnosis, treatment and future directions

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