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Antioxidant Activity and Mechanism of Resveratrol and Polydatin Isolated from Mulberry ( Morus alba L.)

Molecules (Basel, Switzerland), 2021-12, Vol.26 (24), p.7574 [Peer Reviewed Journal]

2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2021 by the authors. 2021 ;ISSN: 1420-3049 ;EISSN: 1420-3049 ;DOI: 10.3390/molecules26247574 ;PMID: 34946655

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Title:
Antioxidant Activity and Mechanism of Resveratrol and Polydatin Isolated from Mulberry ( Morus alba L.)
Author: Li, Ziwei ; Chen, Xiaoman ; Liu, Guo ; Li, Jun ; Zhang, Jinglin ; Cao, Yong ; Miao, Jianyin
Subjects: Antiinfectives and antibacterials ; antioxidant activity ; Antioxidants ; Antioxidants - chemistry ; Antioxidants - pharmacology ; Catalase ; Cosmetics ; Dementia disorders ; extraction ; Food ; Free radicals ; Functional foods & nutraceuticals ; Glucosides - chemistry ; Glucosides - pharmacology ; Glutathione ; Hep G2 Cells ; Humans ; L-Lactate dehydrogenase ; Lactate dehydrogenase ; Lactic acid ; Lipids ; Malondialdehyde ; mechanism ; Metabolism ; Morus - chemistry ; Morus alba ; mulberry ; Oxidative stress ; Oxidative Stress - drug effects ; Physiological effects ; Physiology ; Phytochemicals ; polydatin ; Polyphenols ; Reactive oxygen species ; Resveratrol ; Resveratrol - chemistry ; Resveratrol - pharmacology ; Scavenging ; Stilbene ; Stilbenes - chemistry ; Stilbenes - pharmacology ; Superoxide dismutase
Is Part Of: Molecules (Basel, Switzerland), 2021-12, Vol.26 (24), p.7574
Description: Natural stilbenes have unique physiological effects, such as anti-senile dementia, anti-cancer, anti-bacterial, lowering blood lipid, and other important biological functions, which have attracted great attention from scholars in recent years. In this study, two stilbene compounds, resveratrol (RES) and polydatin (PD), were isolated from Mulberry ( L.), and their antioxidant activity and mechanism were investigated. The results showed that the contents of RES and PD in mulberry roots were 32.45 and 3.15 μg/g, respectively, significantly higher than those in mulberry fruits (0.48 and 0.0020 μg/g) and mulberry branches (5.70 and 0.33 μg/g). Both RES and PD showed high antioxidant potential by DPPH, ABTS free-scavenging methods, and ORAC assay, and provided protection against oxidative damage in HepG2 cells by increased catalase (CAT) activity, superoxide dismutase (SOD) activity, and Glutathione (GSH) content, and decreasing generation of reactive oxygen species (ROS), lactate dehydrogenase (LDH) level, and malondialdehyde (MDA) content. Therefore, RES and PD treatment could be effective for attenuating AAPH-induced oxidative stress in HepG2 cells. This study will promote the development and application of stilbene compounds. Furthermore, the RES and PD could be used as antioxidant supplements in functional foods, cosmetics, or pharmaceuticals, contributing to health improvement.
Publisher: Switzerland: MDPI AG
Language: English
Identifier: ISSN: 1420-3049
EISSN: 1420-3049
DOI: 10.3390/molecules26247574
PMID: 34946655
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
Alma/SFX Local Collection
ProQuest Central
DOAJ Directory of Open Access Journals

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Antioxidant Activity and Mechanism of Resveratrol and Polydatin Isolated from Mulberry ( Morus alba L.)

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