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Lymphoma incidence, survival and prevalence 2004-2014: sub-type analyses from the UK's Haematological Malignancy Research Network

British journal of cancer, 2015-04, Vol.112 (9), p.1575-1584 [Peer Reviewed Journal]

Copyright Nature Publishing Group Apr 28, 2015 ;Copyright © 2015 Cancer Research UK 2015 Cancer Research UK ;ISSN: 0007-0920 ;EISSN: 1532-1827 ;DOI: 10.1038/bjc.2015.94 ;PMID: 25867256 ;CODEN: BJCAAI

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  • Title:
    Lymphoma incidence, survival and prevalence 2004-2014: sub-type analyses from the UK's Haematological Malignancy Research Network
  • Author: Smith, A ; Crouch, S ; Lax, S ; Li, J ; Painter, D ; Howell, D ; Patmore, R ; Jack, A ; Roman, E
  • Subjects: Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Cohort Studies ; Epidemiology ; Female ; Follow-Up Studies ; Hematologic Neoplasms - epidemiology ; Hematologic Neoplasms - mortality ; Humans ; Incidence ; Infant ; Infant, Newborn ; Lymphoma - classification ; Lymphoma - epidemiology ; Lymphoma - mortality ; Male ; Middle Aged ; Prevalence ; Prognosis ; Survival Rate ; United Kingdom - epidemiology ; Young Adult
  • Is Part Of: British journal of cancer, 2015-04, Vol.112 (9), p.1575-1584
  • Description: Population-based information about cancer occurrence and survival are required to inform clinical practice and research; but for most lymphomas data are lacking. Set within a socio-demographically representative UK population of nearly 4 million, lymphoma data (N=5796) are from an established patient cohort. Incidence, survival (overall and relative) and prevalence estimates for >20 subtypes are presented. With few exceptions, males tended to be diagnosed at younger ages and have significantly (P<0.05) higher incidence rates. Differences were greatest at younger ages: the <15 year male/female rate ratio for all subtypes combined being 2.2 (95% CI 1.3-3.4). These gender differences impacted on prevalence; most subtype estimates being significantly (P<0.05) higher in males than females. Outcome varied widely by subtype; survival of patients with nodular lymphocyte predominant Hodgkin lymphoma approached that of the general population, whereas less than a third of those with other B-cell (e.g., mantle cell) or T-cell (e.g., peripheral-T) lymphomas survived for ≥5 years. No males/female survival differences were detected. Major strengths of our study include completeness of ascertainment, world-class diagnostics and generalisability. The marked variations demonstrated confirm the requirement for 'real-world' data to inform aetiological hypotheses, health-care planning and the future monitoring of therapeutic changes.
  • Publisher: England: Nature Publishing Group
  • Language: English
  • Identifier: ISSN: 0007-0920
    EISSN: 1532-1827
    DOI: 10.1038/bjc.2015.94
    PMID: 25867256
    CODEN: BJCAAI
  • Source: Freely Accessible Journals
    MEDLINE
    PubMed Central
    ProQuest Central
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