Language:

Reciprocal organ interactions during heart failure: a position paper from the ESC Working Group on Myocardial Function

Cardiovascular research, 2021-11, Vol.117 (12), p.2416-2433 [Peer Reviewed Journal]

The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology. 2021 ;The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology. ;ISSN: 0008-6363 ;EISSN: 1755-3245 ;DOI: 10.1093/cvr/cvab009 ;PMID: 33483724

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Reciprocal organ interactions during heart failure: a position paper from the ESC Working Group on Myocardial Function
Author: Ciccarelli, Michele ; Dawson, Dana ; Falcao-Pires, Inês ; Giacca, Mauro ; Hamdani, Nazha ; Heymans, Stéphane ; Hooghiemstra, Astrid ; Leeuwis, Annebet ; Hermkens, Dorien ; Tocchetti, Carlo Gabriele ; van der Velden, Jolanda ; Zacchigna, Serena ; Thum, Thomas
Subjects: Animals ; Disease Progression ; Functional Status ; Heart - physiopathology ; Heart Failure, Diastolic - complications ; Heart Failure, Diastolic - mortality ; Heart Failure, Diastolic - physiopathology ; Heart Failure, Diastolic - therapy ; Heart Failure, Systolic - complications ; Heart Failure, Systolic - mortality ; Heart Failure, Systolic - physiopathology ; Heart Failure, Systolic - therapy ; Humans ; Multiple Organ Failure - etiology ; Multiple Organ Failure - mortality ; Multiple Organ Failure - physiopathology ; Multiple Organ Failure - therapy ; Position Paper from European Society of Cardiology Working Group ; Risk Assessment ; Risk Factors
Is Part Of: Cardiovascular research, 2021-11, Vol.117 (12), p.2416-2433
Description: Abstract Heart failure—either with reduced or preserved ejection fraction (HFrEF/HFpEF)—is a clinical syndrome of multifactorial and gender-dependent aetiology, indicating the insufficiency of the heart to pump blood adequately to maintain blood flow to meet the body’s needs. Typical symptoms commonly include shortness of breath, excessive fatigue with impaired exercise capacity, and peripheral oedema, thereby alluding to the fact that heart failure is a syndrome that affects multiple organ systems. Patients suffering from progressed heart failure have a very limited life expectancy, lower than that of numerous cancer types. In this position paper, we provide an overview regarding interactions between the heart and other organ systems, the clinical evidence, underlying mechanisms, potential available or yet-to-establish animal models to study such interactions and finally discuss potential new drug interventions to be developed in the future. Our working group suggests that more experimental research is required to understand the individual molecular mechanisms underlying heart failure and reinforces the urgency for tailored therapeutic interventions that target not only the heart but also other related affected organ systems to effectively treat heart failure as a clinical syndrome that affects and involves multiple organs.
Publisher: England: Oxford University Press
Language: English
Identifier: ISSN: 0008-6363
EISSN: 1755-3245
DOI: 10.1093/cvr/cvab009
PMID: 33483724
Source: Oxford Journals Open Access Collection
GFMER Free Medical Journals
MEDLINE
Alma/SFX Local Collection

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Reciprocal organ interactions during heart failure: a position paper from the ESC Working Group on Myocardial Function

The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology. 2021 ;The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology. ;ISSN: 0008-6363 ;EISSN: 1755-3245 ;DOI: 10.1093/cvr/cvab009 ;PMID: 33483724

Searching Remote Databases, Please Wait