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Soluble Vascular Adhesion Protein-1 Correlates With Cardiovascular Risk Factors and Early Atherosclerotic Manifestations

Arteriosclerosis, thrombosis, and vascular biology, 2012-02, Vol.32 (2), p.523-532 [Peer Reviewed Journal]

2012 American Heart Association, Inc. ;2015 INIST-CNRS ;ISSN: 1079-5642 ;EISSN: 1524-4636 ;DOI: 10.1161/ATVBAHA.111.238030 ;PMID: 22116093 ;CODEN: ATVBFA

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Title:
Soluble Vascular Adhesion Protein-1 Correlates With Cardiovascular Risk Factors and Early Atherosclerotic Manifestations
Author: Aalto, Kristiina ; Maksimow, Mikael ; Juonala, Markus ; Viikari, Jorma ; Jula, Antti ; Kähönen, Mika ; Jalkanen, Sirpa ; Raitakari, Olli T ; Salmi, Marko
Subjects: Adult ; Amine Oxidase (Copper-Containing) - blood ; Atherosclerosis (general aspects, experimental research) ; Atherosclerosis - blood ; Atherosclerosis - epidemiology ; Atherosclerosis - ethnology ; Biological and medical sciences ; Biomarkers - blood ; Blood and lymphatic vessels ; Blood Pressure - physiology ; Body Mass Index ; Cardiology. Vascular system ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - ethnology ; Carotid Intima-Media Thickness ; Carotid Stenosis - blood ; Carotid Stenosis - epidemiology ; Carotid Stenosis - ethnology ; Cell Adhesion Molecules - blood ; Cohort Studies ; Coronary heart disease ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Female ; Finland ; Heart ; High-Throughput Screening Assays - methods ; Humans ; Incidence ; Male ; Medical sciences ; Middle Aged ; Retrospective Studies ; Risk Factors ; Sex Characteristics
Is Part Of: Arteriosclerosis, thrombosis, and vascular biology, 2012-02, Vol.32 (2), p.523-532
Description: OBJECTIVE—Vascular adhesion protein-1 is an endothelial enzyme that regulates leukocyte traffic and contributes to vascular damage in animal models. The relations of soluble vascular adhesion protein-1 (sVAP-1) with cardiovascular risk factors and markers of subclinical atherosclerosis at a population level have not been studied. METHODS AND RESULTS—We developed a new high-throughput method and measured sVAP-1 activities in serum of 2183 persons (The Cardiovascular Risk in Young Finns Study). In women, sVAP-1 activity correlated indirectly with body mass index (r=−0.15, P<0.0001), triglycerides (r=−0.13, P<0.0001), C-reactive protein (r=−0.23; P<0.0001), and brachial artery flow-mediated vasodilatation (r=−0.076, P=0.0089) and directly with carotid plaques (r=0.066, P=0.023). None of these correlations was significant in men. In women, all these univariate correlations remained significant after adjustment for body mass index, and direct correlations with LDL-cholesterol (r=0.094, P=0.0014) and carotid intima-media thickness (r=0.075, P=0.010) became evident. In men, sVAP-1 activity associated directly with glucose (r=0.074, P=0.020), intima-media thickness (r=0.072, P=0.025), metabolic syndrome (P=0.016), and type 1 (P=0.0002) and type 2 (P<0.0001) diabetes. In multivariable analyses, sVAP-1 activity was an independent determinant of carotid intima-media thickness (P=0.0072) and plaques [odds ratio 1.71 (95% confidence interval 1.07–2.72, P=0.025] in women, but not in men. CONCLUSION—sVAP-1 activity correlates directly with intima-media thickness and carotid plaques in general population and may play a role in the pathophysiology of preclinical atherosclerosis.
Publisher: Philadelphia, PA: American Heart Association, Inc
Language: English
Identifier: ISSN: 1079-5642
EISSN: 1524-4636
DOI: 10.1161/ATVBAHA.111.238030
PMID: 22116093
CODEN: ATVBFA
Source: Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
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