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Polymyalgia rheumatica and remitting seronegative symmetrical synovitis with pitting edema following intravesical instillation of bacillus Calmette-Guerin

Reumatologia, 2019, Vol.57 (4), p.249-252 [Peer Reviewed Journal]

2019. This work is published under http://creativecommons.org/licenses/by-nc-sa/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;Copyright: © 2019 Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie 2019 ;ISSN: 0034-6233 ;EISSN: 2084-9834 ;DOI: 10.5114/reum.2019.87617 ;PMID: 31548753

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  • Title:
    Polymyalgia rheumatica and remitting seronegative symmetrical synovitis with pitting edema following intravesical instillation of bacillus Calmette-Guerin
  • Author: Manzo, Ciro
  • Subjects: bacillus calmette-guerin ; Bacillus Calmette-Guerin vaccine ; BCG ; Case Report ; Edema ; Genetic factors ; Immune system ; Immunotherapy ; Invasiveness ; Pain ; Polymyalgia rheumatica ; Prednisone ; remitting seronegative symmetrical synovitis with pitting edema ; Senescence ; Synovitis
  • Is Part Of: Reumatologia, 2019, Vol.57 (4), p.249-252
  • Description: Intravesical instillation of bacillus Calmette-Guerin (BCG) after transurethral cancer resection is an approved part of the management of non-muscle invasive bladder cancer (NMIBC). The onset of polymyalgia rheumatica (PMR) and remitting seronegative symmetrical synovitis with pitting edema (RS3PE) following this immunotherapy is anecdotal. We report the case of a 69-year-old male patient suffering from boxing-glove swelling of the hand associated with bilateral pain, aching and stiffness in the shoulders and pelvic girdles, which occurred after a cycle of six intravesical instillations of BCG. Polymyalgia rheumatica associated with RS3PE was diagnosed, prednisone therapy started and definitively stopped after 13 months. During a 16-year follow-up, no alternative diagnosis was possible. The role of genetic factors and of the senescence of the immune system is discussed. According to our best knowledge, this is the first case report of PMR associated with RS3PE following intravesical instillation of BCG.
  • Publisher: Warsaw: Termedia Publishing House
  • Language: English;Polish
  • Identifier: ISSN: 0034-6233
    EISSN: 2084-9834
    DOI: 10.5114/reum.2019.87617
    PMID: 31548753
  • Source: DOAJ Directory of Open Access Journals
    AUTh Library subscriptions: ProQuest Central
    PubMed Central
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