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Neuron somal size is decreased in the lateral amygdalar nucleus of subjects with bipolar disorder

Journal of psychiatry & neuroscience, 2007-05, Vol.32 (3), p.203-210 [Peer Reviewed Journal]

Canadian Medical Association ;2007 INIST-CNRS ;COPYRIGHT 2007 CMA Impact Inc. ;COPYRIGHT 2007 Joule Inc. ;Copyright Canadian Medical Association May 2007 ;2007 Canadian Medical Association ;ISSN: 1180-4882 ;EISSN: 1488-2434 ;DOI: 10.1016/S1180-4882(07)50031-4 ;PMID: 17476367 ;CODEN: JPNEEF

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Title:
Neuron somal size is decreased in the lateral amygdalar nucleus of subjects with bipolar disorder
Author: Bezchlibnyk, Yarema B., PhD ; Sun, Xiujun., MB ; Wang, Jun-Feng., MD,PhD ; MacQueen, Glenda M., PhD ; McEwen, Bruce S., MD,PhD ; Young, L.Trevor., MD,PhD
Subjects: Adult ; Adult and adolescent clinical studies ; Aged ; Amygdala (Brain) ; Amygdala - pathology ; Biological and medical sciences ; Bipolar disorder ; Bipolar Disorder - pathology ; Bipolar disorders ; Brain ; Brain research ; Care and treatment ; Cell Size ; Density ; Depressive Disorder, Major - pathology ; Female ; Functional Laterality - physiology ; Fundamental and applied biological sciences. Psychology ; Humans ; Male ; Medical Education ; Medical sciences ; Middle Aged ; Mood disorders ; Neuroglia ; Neuroglia - pathology ; Neurological disorders ; Neurons - pathology ; Psychiatry ; Psychoanalysis ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychopathology. Psychiatry ; Research Paper ; Retrograde Degeneration - pathology
Is Part Of: Journal of psychiatry & neuroscience, 2007-05, Vol.32 (3), p.203-210
Description: Objective Morphometric studies of postmortem brains from subjects with mood disorders have reported altered density of glial cells in the amygdala; however, the nuclear regions have not been examined individually. Methods We assessed the size and density of both neuronal and glial cells in discrete amygdalar nuclei in postmortem sections from subjects with major depressive disorder, bipolar disorder (BD) and schizophrenia and from nonpsychiatric control subjects. Three adjacent Nissl-stained sections were examined from each individual. Results We report significantly decreased neuron somal size in the lateral amygdalar nucleus (LAN) and the accessory basal parvocellular nucleus (ABPC) in subjects with BD, relative to control subjects. These changes in cellular morphology were most prominent in the LAN in sections obtained from the left hemisphere. Conclusions These findings add to increasing evidence for neuropathological changes in the amygdala of subjects with BD and specifically implicate the LAN and ABPC in this disorder.
Publisher: Ottawa, ON: Canadian Medical Association
Language: French;English
Identifier: ISSN: 1180-4882
EISSN: 1488-2434
DOI: 10.1016/S1180-4882(07)50031-4
PMID: 17476367
CODEN: JPNEEF
Source: ProQuest One Psychology
GFMER Free Medical Journals
MEDLINE
PubMed Central
Alma/SFX Local Collection
ProQuest Central

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Neuron somal size is decreased in the lateral amygdalar nucleus of subjects with bipolar disorder

Canadian Medical Association ;2007 INIST-CNRS ;COPYRIGHT 2007 CMA Impact Inc. ;COPYRIGHT 2007 Joule Inc. ;Copyright Canadian Medical Association May 2007 ;2007 Canadian Medical Association ;ISSN: 1180-4882 ;EISSN: 1488-2434 ;DOI: 10.1016/S1180-4882(07)50031-4 ;PMID: 17476367 ;CODEN: JPNEEF

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