Language:

The effect of sperm DNA fragmentation on intracytoplasmic sperm injection outcome

2021 The Authors. Andrologia published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 ;ISSN: 0303-4569 ;EISSN: 1439-0272 ;DOI: 10.1111/and.14180

Digital Resources/Online E-Resources

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
The effect of sperm DNA fragmentation on intracytoplasmic sperm injection outcome
Author: Khalafalla, K ; Majzoub, A ; Elbardisi, H ; Bhathella, A ; Chaudhari, A ; Agarwal, A ; Henkel, R ; AlMarzooki, T ; Burjaq, H ; Arafa, M
Subjects: 1103 Clinical Sciences ; 1114 Paediatrics and Reproductive Medicine ; Adult ; Andrology ; CHROMATIN DISPERSION ; clinical reproductive outcomes ; DAMAGE ; DEOXYRIBONUCLEIC-ACID FRAGMENTATION ; DNA Fragmentation ; Endocrinology & Metabolism ; Female ; FERTILIZATION ; Fertilization in Vitro ; Humans ; ICSI ; INDEX ; intracytoplasmic sperm injection ; IVF ; Life Sciences & Biomedicine ; Male ; MALE AGE ; Obstetrics & Reproductive Medicine ; PREGNANCY ; Retrospective Studies ; Science & Technology ; sperm chromatin dispersion test ; sperm DNA fragmentation ; Sperm Injections, Intracytoplasmic ; Spermatozoa
Description: Our study objective was to assess the effect of various sperm DNA fragmentation levels on clinical intracytoplasmic sperm injection outcome. This retrospective study included 392 patients who underwent ICSI and performed sperm DNA fragmentation testing before the procedure. Based on sperm DNA fragmentation cut-off values, the patients were differentiated into 3 groups as <20%, 20%–30% and >30%. According to the female status, patients were differentiated into favourable group (n = 259) with female age <35 years and anti-Mullerian hormone level ≥7.1 pmol/L; and unfavourable group (n = 133) with female age ≥35 years and anti-Mullerian hormone level ≤7.1 pmol/L. The patient's medical records were reviewed, and patient's demographic, laboratory data including semen analysis, sperm DNA fragmentation determined by means of sperm chromatin dispersion, hormonal profile and data regarding intracytoplasmic sperm injection cycle were collected. This cohort reported that the clinical reproductive outcomes of intracytoplasmic sperm injection showed no statistical significance with increase sperm DNA fragmentation levels. In sperm DNA fragmentation above 30%, favourable females had significantly higher clinical pregnancy rate and live birth rate than unfavourable females, while fertilisation rate and miscarriage rate showed no significance between the subgroups. High sperm DNA fragmentation is linked to poor semen parameters.
Publisher: Wiley
Creation Date: 2021-06
Language: English
Identifier: ISSN: 0303-4569
EISSN: 1439-0272
DOI: 10.1111/and.14180
Source: Spiral

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

The effect of sperm DNA fragmentation on intracytoplasmic sperm injection outcome

Searching Remote Databases, Please Wait