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1-2 Drinks Per Day Affect Lipoprotein Composition after 3 Weeks-Results from a Cross-Over Pilot Intervention Trial in Healthy Adults Using Nuclear Magnetic Resonance-Measured Lipoproteins and Apolipoproteins

Nutrients, 2022-11, Vol.14 (23), p.5043 [Peer Reviewed Journal]

COPYRIGHT 2022 MDPI AG ;2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2022 by the authors. 2022 ;ISSN: 2072-6643 ;EISSN: 2072-6643 ;DOI: 10.3390/nu14235043 ;PMID: 36501072

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Title:
1-2 Drinks Per Day Affect Lipoprotein Composition after 3 Weeks-Results from a Cross-Over Pilot Intervention Trial in Healthy Adults Using Nuclear Magnetic Resonance-Measured Lipoproteins and Apolipoproteins
Author: Wilkens, Trine Levring ; Ziegler, Zabrina ; Aru, Violetta ; Khakimov, Bekzod ; Overgaard, Snædís Lilja ; Engelsen, Søren Balling ; Dragsted, Lars Ove
Subjects: Adult ; Adults ; Alcohol use ; Alcoholic beverages ; apoA1 ; apoB ; Apolipoproteins ; Apolipoproteins B ; Beverages ; Biomarkers ; Blood lipids ; cardiovascular disease ; Cardiovascular diseases ; Cholesterol ; Cholesterol, HDL ; Coronary artery disease ; Coronary heart disease ; Cross-Over Studies ; Drinking of alcoholic beverages ; Female ; HDL ; Health aspects ; Health risks ; Heart diseases ; High density lipoprotein ; Humans ; Lipoproteins ; Low density lipoprotein ; Low density lipoproteins ; Magnetic Resonance Spectroscopy ; Male ; moderate alcohol consumption ; NMR ; Nuclear magnetic resonance ; Phospholipids ; Physiological aspects ; Pilot Projects ; Prevention ; Resonance ; Spectrum analysis ; Womens health
Is Part Of: Nutrients, 2022-11, Vol.14 (23), p.5043
Description: Alcohol consumption ranging from 1−2 drinks/day associates with a lower risk of coronary heart disease in some studies. The underlying mechanisms are unclear. The Metabolic Imprints of Alcoholic Beverages (MetAl) trial aimed to explore the short-term effects of moderate alcohol consumption on cardiovascular biomarkers. A 2 × 3-week cross-over single-blinded intervention trial investigating the effect of 1−2 drinks/day (~12−24 g) compared with abstention on 1H Nuclear Magnetic Resonance-measured main lipoproteins and subfractions was performed in 26 healthy adults. Volunteers were classified as occasional or habitual drinkers based on their habitual alcohol intakes (<2 or ≥2 drinks/week). Compared with abstention, 1−2 drinks/day increased HDL2a-C (p = 0.004), HDL3-C (p = 0.008), and HDL non-significantly (p = 0.19). Total apoA1 and apoA1 in HDL and its subfractions increased (p < 0.05). Novel findings were a decreased apoB/apoA1 ratio (p = 0.02), and increased HDL2a phospholipid content (p = 0.04). In women alone, the results were similar but attenuated, and LDL-P decreased. Thus, changes in apoA1- and HDL-related biomarkers occur within weeks in moderate drinkers. Compared with abstention, 1−2 drinks/day increased total apoA1 more strongly than HDL-C and increased the cholesterol, apoA1, and phospholipid content of several HDL subfractions. Whether this provides a cardiovascular benefit requires further study. Clinicaltrials.gov: NCT03384147.
Publisher: Switzerland: MDPI AG
Language: English
Identifier: ISSN: 2072-6643
EISSN: 2072-6643
DOI: 10.3390/nu14235043
PMID: 36501072
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
ROAD: Directory of Open Access Scholarly Resources
ProQuest Central
DOAJ Directory of Open Access Journals

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1-2 Drinks Per Day Affect Lipoprotein Composition after 3 Weeks-Results from a Cross-Over Pilot Intervention Trial in Healthy Adults Using Nuclear Magnetic Resonance-Measured Lipoproteins and Apolipoproteins

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