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Successful treatment using apatinib in intractable brain edema: A case report and literatures review

Cancer biology & therapy, 2018-12, Vol.19 (12), p.1093-1096 [Peer Reviewed Journal]

2018 The Author(s). Published by Taylor & Francis. 2018 The Author(s) ;ISSN: 1538-4047 ;EISSN: 1555-8576 ;DOI: 10.1080/15384047.2018.1491502 ;PMID: 30081717

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Title:
Successful treatment using apatinib in intractable brain edema: A case report and literatures review
Author: Song, MD, PhD, Yanqiu ; Liu, MD, PhD, Bailong ; Guan, Master of Medicine, Meng ; Liu, Min
Subjects: Antineoplastic Agents - administration & dosage ; Antineoplastic Agents - adverse effects ; Antineoplastic Agents - therapeutic use ; Bedside to Bench Report ; Biomarkers, Tumor ; Brain Edema - diagnosis ; Brain Edema - drug therapy ; Brain Edema - etiology ; Brain Neoplasms - complications ; Brain Neoplasms - diagnosis ; Brain Neoplasms - drug therapy ; Brain Neoplasms - radiotherapy ; Capillary Permeability ; Female ; Humans ; Immunohistochemistry ; Magnetic Resonance Imaging ; Middle Aged ; Protein Kinase Inhibitors - administration & dosage ; Protein Kinase Inhibitors - adverse effects ; Protein Kinase Inhibitors - therapeutic use ; Pyridines - administration & dosage ; Pyridines - adverse effects ; Pyridines - therapeutic use ; Radiotherapy - adverse effects ; Radiotherapy - methods ; Treatment Outcome ; Vascular Endothelial Growth Factor A - metabolism
Is Part Of: Cancer biology & therapy, 2018-12, Vol.19 (12), p.1093-1096
Description: The treatment of intractable vasogenic brain edema (VBE) caused by tumor and irradiation is challenging. Traditional intervention strategy includes dehydration and glucocorticoids accompanied by obvious side effects and minor effects after long-term use. Novel treatment needs to be found urgently. Recently, vascular endothelial growth factor (VEGF)/VEGFR pathway has been revealed to be essential in VBE. Therefore, tyrosine kinase inhibitor (TKI) targeting VEGFR which blocks (VEGF)/VEGFR signal might be effective. However, such reports have seldom been described. Herein, we documented a heavily-treated breast cancer patient experienced progressive aphasia, limb activity disorder and intermittent convulsion 10 months after radiotherapy of brain metastasis (BM). Cranial MRI demonstrated large peritumoral brain edema (PTBE). High dose of steriods and dehydration had no improvement. Apatinib with a dose of 250mg daily was initiated and all her discomforts disappeared after 10 days of use. The brain MRI of taking apatinib 5 weeks demonstrated remarkable shrinkage of edema. Our case indicates that apatinib, a potent small-molecular TKI targeted VEGFR2 is promising for intractable VBE for satisfactory efficacy and safety. This case is of great value in its rarity and because it provides new insight into PTBE management in clinical practice.
Publisher: United States: Taylor & Francis
Language: English
Identifier: ISSN: 1538-4047
EISSN: 1555-8576
DOI: 10.1080/15384047.2018.1491502
PMID: 30081717
Source: MEDLINE
PubMed Central
Alma/SFX Local Collection

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Successful treatment using apatinib in intractable brain edema: A case report and literatures review

2018 The Author(s). Published by Taylor & Francis. 2018 The Author(s) ;ISSN: 1538-4047 ;EISSN: 1555-8576 ;DOI: 10.1080/15384047.2018.1491502 ;PMID: 30081717

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