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Meta-analysis: melatonin for the treatment of primary sleep disorders

PloS one, 2013-05, Vol.8 (5), p.e63773-e63773 [Peer Reviewed Journal]

COPYRIGHT 2013 Public Library of Science ;COPYRIGHT 2013 Public Library of Science ;2013 Ferracioli-Oda et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2013 Ferracioli-Oda et al 2013 Ferracioli-Oda et al ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0063773 ;PMID: 23691095

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  • Title:
    Meta-analysis: melatonin for the treatment of primary sleep disorders
  • Author: Ferracioli-Oda, Eduardo ; Qawasmi, Ahmad ; Bloch, Michael H
  • Romanovsky, Andrej A.
  • Subjects: Adults ; Children ; Children & youth ; Clinical trials ; Comparative analysis ; Disorders ; Drug dosages ; Drug therapy ; Effectiveness ; Humans ; Insomnia ; Latency ; Medical ethics ; Medical research ; Medicine ; Medicine, Experimental ; Melatonin ; Melatonin - therapeutic use ; Meta-analysis ; Pharmacology ; Psychiatry ; PubMed ; Quality ; Regression Analysis ; Sleep ; Sleep disorders ; Sleep Wake Disorders - drug therapy ; Studies ; Time Factors ; Treatment Outcome
  • Is Part Of: PloS one, 2013-05, Vol.8 (5), p.e63773-e63773
  • Description: To investigate the efficacy of melatonin compared to placebo in improving sleep parameters in patients with primary sleep disorders. PubMed was searched for randomized, placebo-controlled trials examining the effects of melatonin for the treatment of primary sleep disorders. Primary outcomes examined were improvement in sleep latency, sleep quality and total sleep time. Meta-regression was performed to examine the influence of dose and duration of melatonin on reported efficacy. Adults and children diagnosed with primary sleep disorders. Melatonin compared to placebo. Nineteen studies involving 1683 subjects were included in this meta-analysis. Melatonin demonstrated significant efficacy in reducing sleep latency (weighted mean difference (WMD) = 7.06 minutes [95% CI 4.37 to 9.75], Z = 5.15, p<0.001) and increasing total sleep time (WMD = 8.25 minutes [95% CI 1.74 to 14.75], Z = 2.48, p = 0.013). Trials with longer duration and using higher doses of melatonin demonstrated greater effects on decreasing sleep latency and increasing total sleep time. Overall sleep quality was significantly improved in subjects taking melatonin (standardized mean difference = 0.22 [95% CI: 0.12 to 0.32], Z = 4.52, p<0.001) compared to placebo. No significant effects of trial duration and melatonin dose were observed on sleep quality. This meta-analysis demonstrates that melatonin decreases sleep onset latency, increases total sleep time and improves overall sleep quality. The effects of melatonin on sleep are modest but do not appear to dissipate with continued melatonin use. Although the absolute benefit of melatonin compared to placebo is smaller than other pharmacological treatments for insomnia, melatonin may have a role in the treatment of insomnia given its relatively benign side-effect profile compared to these agents.
  • Publisher: United States: Public Library of Science
  • Language: English
  • Identifier: ISSN: 1932-6203
    EISSN: 1932-6203
    DOI: 10.1371/journal.pone.0063773
    PMID: 23691095
  • Source: Public Library of Science (PLoS) Journals Open Access
    GFMER Free Medical Journals
    MEDLINE
    PubMed Central
    ProQuest Central
    DOAJ Directory of Open Access Journals
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