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Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior

Science (American Association for the Advancement of Science), 2019-08, Vol.365 (6456), p.882 [Peer Reviewed Journal]

Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. ;Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works ;ISSN: 0036-8075 ;ISSN: 1095-9203 ;EISSN: 1095-9203 ;DOI: 10.1126/science.aat7693 ;PMID: 31467194

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Title:
Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior
Author: Ganna, Andrea ; Verweij, Karin J H ; Nivard, Michel G ; Maier, Robert ; Wedow, Robbee ; Busch, Alexander S ; Abdellaoui, Abdel ; Guo, Shengru ; Sathirapongsasuti, J Fah ; Lichtenstein, Paul ; Lundström, Sebastian ; Långström, Niklas ; Auton, Adam ; Harris, Kathleen Mullan ; Beecham, Gary W ; Martin, Eden R ; Sanders, Alan R ; Perry, John R B ; Neale, Benjamin M ; Zietsch, Brendan P
Subjects: Biology ; Cannabis ; Complexity ; Confidence intervals ; Correlation ; Correlation coefficient ; Correlation coefficients ; Datasets as Topic ; disease ; Effect Size ; Family studies ; Female ; Females ; general-population ; Genes ; Genetic diversity ; Genetic effects ; Genetic variance ; Genetics ; genome-wide association ; Genome-wide association studies ; Genome-Wide Association Study ; Genomes ; Homosexual behavior ; homosexuality ; Homosexuality, Female - genetics ; Homosexuality, Male - genetics ; Humans ; linkage ; Loci ; Male ; Males ; Medical Genetics ; Medicin och hälsovetenskap ; Medicinsk genetik ; Menopause ; Meta Analysis ; Olfaction ; orientation ; Personality Traits ; Phenotype ; Polygenic inheritance ; Polymorphism, Single Nucleotide ; psychiatric-disorders ; Psychological Characteristics ; Quantitative Trait Loci ; Replication ; Risk taking ; Samples ; schizophrenia ; Science & Technology - Other Topics ; Searching ; Sex ; Sex hormones ; Sexes ; Sexual behavior ; Sexual orientation ; Sexual partners ; Sexuality ; Smoking ; Statistical analysis ; Statistical methods ; Statistics ; Studies ; trait ; Twins ; United Kingdom ; Workshops
Is Part Of: Science (American Association for the Advancement of Science), 2019-08, Vol.365 (6456), p.882
Description: Twin and family studies have shown that same-sex sexual behavior is partly genetically influenced, but previous searches for specific genes involved have been underpowered. We performed a genome-wide association study (GWAS) on 477,522 individuals, revealing five loci significantly associated with same-sex sexual behavior. In aggregate, all tested genetic variants accounted for 8 to 25% of variation in same-sex sexual behavior, only partially overlapped between males and females, and do not allow meaningful prediction of an individual's sexual behavior. Comparing these GWAS results with those for the proportion of same-sex to total number of sexual partners among nonheterosexuals suggests that there is no single continuum from opposite-sex to same-sex sexual behavior. Overall, our findings provide insights into the genetics underlying same-sex sexual behavior and underscore the complexity of sexuality.
Publisher: United States: The American Association for the Advancement of Science
Language: English
Identifier: ISSN: 0036-8075
ISSN: 1095-9203
EISSN: 1095-9203
DOI: 10.1126/science.aat7693
PMID: 31467194
Source: SWEPUB Freely available online

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Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior

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