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Spontaneous Resolution of Genital Chlamydia trachomatis Infection in Women and Protection from Reinfection

The Journal of infectious diseases, 2013-06, Vol.207 (12), p.1850-1856 [Peer Reviewed Journal]

Copyright © 2013 Oxford University Press on behalf of the Infectious Diseases Society of America ;2014 INIST-CNRS ;The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: . 2013 ;ISSN: 0022-1899 ;EISSN: 1537-6613 ;DOI: 10.1093/infdis/jit094 ;PMID: 23470847 ;CODEN: JIDIAQ

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Title:
Spontaneous Resolution of Genital Chlamydia trachomatis Infection in Women and Protection from Reinfection
Author: Geisler, William M. ; Lensing, Shelly Y. ; Press, Christen G. ; Hook, Edward W.
Subjects: Adolescent ; Adult ; Anti-Bacterial Agents - therapeutic use ; Azithromycin - therapeutic use ; BACTERIA ; Bacteriology ; Biological and medical sciences ; Chlamydia ; Chlamydia Infections - drug therapy ; Chlamydia Infections - immunology ; Chlamydia Infections - microbiology ; Chlamydia Infections - prevention & control ; Chlamydia trachomatis ; Chlamydia trachomatis - physiology ; Cohort Studies ; Disease risks ; Female ; Follow-Up Studies ; Fundamental and applied biological sciences. Psychology ; Genital Diseases, Female - drug therapy ; Genital Diseases, Female - immunology ; Genital Diseases, Female - microbiology ; Genital Diseases, Female - prevention & control ; Genitalia ; Humans ; Immunity ; Infections ; Infectious diseases ; Major and Brief Reports ; Medical sciences ; Microbiology ; Middle Aged ; Miscellaneous ; Natural history ; Prospective Studies ; Reinfection ; Remission, Spontaneous ; Risk Factors ; Screening tests ; Secondary Prevention ; Sexually transmitted diseases ; Young Adult
Is Part Of: The Journal of infectious diseases, 2013-06, Vol.207 (12), p.1850-1856
Description: The natural history of chlamydia is variable and may include persisting asymptomatic infection, complications, or spontaneous resolution before treatment. Reinfection is common. We evaluated whether spontaneous resolution was associated with decreased reinfection in women returning for treatment of a positive chlamydia screening test. At enrollment, participants were tested for chlamydia, treated with azithromycin, and scheduled for a 6-month follow-up visit for repeat testing. Two hundred participants returned 1 to 12 months after treatment. Spontaneous resolution at enrollment was demonstrated in 44 (22.0%). Reinfection at follow-up occurred in 33 (16.5%), being more frequent in those with persisting infection at enrollment versus spontaneous resolution (31 of 156 [19.9%] vs 2 of 44 [4.5%]; P = .016). Adjusting for age, the odds of reinfection was 4 times higher for participants with persisting infection at enrollment (odds ratio 4.0, 95% confidence interval, 1.1—25.6; P = .034). Chlamydia treatment may attenuate protective immunity in some patients.
Publisher: Oxford: Oxford University Press
Language: English
Identifier: ISSN: 0022-1899
EISSN: 1537-6613
DOI: 10.1093/infdis/jit094
PMID: 23470847
CODEN: JIDIAQ
Source: Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
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Spontaneous Resolution of Genital Chlamydia trachomatis Infection in Women and Protection from Reinfection

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