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Targeting breast cancer stem cells by dendritic cell vaccination in humanized mice with breast tumor: preliminary results

OncoTargets and therapy, 2016-01, Vol.9, p.4441-4451 [Peer Reviewed Journal]

COPYRIGHT 2016 Dove Medical Press Limited ;COPYRIGHT 2016 Dove Medical Press Limited ;2016. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2016 Pham et al. This work is published and licensed by Dove Medical Press Limited 2016 ;ISSN: 1178-6930 ;EISSN: 1178-6930 ;DOI: 10.2147/OTT.S105239 ;PMID: 27499638

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Title:
Targeting breast cancer stem cells by dendritic cell vaccination in humanized mice with breast tumor: preliminary results
Author: Pham, Phuc Van ; Le, Hanh Thi ; Vu, Binh Thanh ; Pham, Viet Quoc ; Le, Phong Minh ; Phan, Nhan Lu-Chinh ; Trinh, Ngu Van ; Nguyen, Huyen Thi-Lam ; Nguyen, Sinh Truong ; Nguyen, Toan Linh ; Phan, Ngoc Kim
Subjects: Antigens ; Breast cancer ; Cancer cells ; Cancer therapies ; Care and treatment ; Cytokines ; Dendritic cells ; Development and progression ; FDA approval ; Growth factors ; Health aspects ; Innovations ; Laboratory animals ; Medical immunity ; Medical research ; Melanoma ; Methods ; Molecular targeted therapy ; Original Research ; Prostate cancer ; Stem cells ; Testing ; Tumors ; Umbilical cord
Is Part Of: OncoTargets and therapy, 2016-01, Vol.9, p.4441-4451
Description: Breast cancer (BC) is one of the leading cancers in women. Recent progress has enabled BC to be cured with high efficiency. However, late detection or metastatic disease often renders the disease untreatable. Additionally, relapse is the main cause of death in BC patients. Breast cancer stem cells (BCSCs) are considered to cause the development of BC and are thought to be responsible for metastasis and relapse. This study aimed to target BCSCs using dendritic cells (DCs) to treat tumor-bearing humanized mice models. NOD/SCID mice were used to produce the humanized mice by transplantation of human hematopoietic stem cells. Human BCSCs were injected into the mammary fat pad to produce BC humanized mice. Both hematopoietic stem cells and DCs were isolated from the human umbilical cord blood, and immature DCs were produced from cultured mononuclear cells. DCs were matured by BCSC-derived antigen incubation for 48 hours. Mature DCs were vaccinated to BC humanized mice with a dose of 10(6) cells/mice, and the survival percentage was monitored in both treated and untreated groups. The results showed that DC vaccination could target BCSCs and reduce the tumor size and prolong survival. These results suggested that targeting BCSCs with DCs is a promising therapy for BC.
Publisher: New Zealand: Dove Medical Press Limited
Language: English
Identifier: ISSN: 1178-6930
EISSN: 1178-6930
DOI: 10.2147/OTT.S105239
PMID: 27499638
Source: GFMER Free Medical Journals
PubMed Central
DOVE Medical Press Journals
ROAD: Directory of Open Access Scholarly Resources
ProQuest Central
DOAJ Directory of Open Access Journals

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Targeting breast cancer stem cells by dendritic cell vaccination in humanized mice with breast tumor: preliminary results

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