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Effects of pyruvate and lactate on food intake in rat strains sensitive and resistant to dietary obesity

Physiology & behavior, 1996-03, Vol.59 (3), p.555-560 [Peer Reviewed Journal]

1996 ;1996 INIST-CNRS ;ISSN: 0031-9384 ;EISSN: 1873-507X ;DOI: 10.1016/0031-9384(95)02109-4 ;PMID: 8700960

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Title:
Effects of pyruvate and lactate on food intake in rat strains sensitive and resistant to dietary obesity
Author: Nagase, H. ; Bray, G.A. ; York, D.A.
Subjects: Animals ; Biological and medical sciences ; Body Weight - drug effects ; Diet ; Diet, Fat-Restricted ; Dietary Fats - pharmacology ; Eating - drug effects ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; Hepatic vagotomy ; High fat diet ; Lactates - pharmacology ; Lactic Acid ; Liver - innervation ; Low fat diet ; Male ; Obesity - genetics ; Obesity - psychology ; OM Rats ; Pyruvates - pharmacology ; Pyruvic Acid ; Rats ; Rats, Inbred Strains ; S5B/P1 Rats ; Species Specificity ; Vagus Nerve - physiology ; Vertebrates: anatomy and physiology, studies on body, several organs or systems
Is Part Of: Physiology & behavior, 1996-03, Vol.59 (3), p.555-560
Description: We have investigated the effects of peripherally administered pyruvate and lactate on the intake of high fat (HF) and low fat (LF) diets by a strain of rat either sensitive (Osborne-Mendel, OM) or resistant (SSB/P1) to high fat-induced obesity. Both pyruvate and lactate inhibited the intake of HF and LF diets by OM rats and these effects were blocked by selective hepatic vagotomy. In contrast, in S5B/P1 rats fed an LF diet the responses to pyruvate and lactate were attenuated and were absent in S5B/P1 rats fed the HF diet. These data suggest that OM and S5B/P1 rats differ either in their metabolism of pyruvate and lactate or in their responses to these metabolites.
Publisher: Cambridge: Elsevier Inc
Language: English
Identifier: ISSN: 0031-9384
EISSN: 1873-507X
DOI: 10.1016/0031-9384(95)02109-4
PMID: 8700960
Source: MEDLINE
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Effects of pyruvate and lactate on food intake in rat strains sensitive and resistant to dietary obesity

1996 ;1996 INIST-CNRS ;ISSN: 0031-9384 ;EISSN: 1873-507X ;DOI: 10.1016/0031-9384(95)02109-4 ;PMID: 8700960

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