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Sex differences in relation to conditioned fear-induced enhancement of morphine analgesia

Physiology & behavior, 2001-02, Vol.72 (3), p.439-447 [Peer Reviewed Journal]

2001 Elsevier Science Inc. ;2001 INIST-CNRS ;ISSN: 0031-9384 ;EISSN: 1873-507X ;DOI: 10.1016/S0031-9384(00)00426-1 ;PMID: 11274689

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Title:
Sex differences in relation to conditioned fear-induced enhancement of morphine analgesia
Author: Stock, Howard S ; Caldarone, Barbara ; Abrahamsen, Glenn ; Mongeluzi, Donna ; Wilson, Marlene A ; Rosellini, Robert A
Subjects: Analgesia ; Analgesics, Opioid - pharmacology ; Animal ; Animals ; Behavior, Animal - drug effects ; Biological and medical sciences ; Conditioned fear ; Conditioning ; Conditioning (Psychology) - physiology ; Estrogens - physiology ; Estrus - drug effects ; Estrus - physiology ; Fear - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Learning. Memory ; Male ; Morphine ; Morphine - pharmacology ; Pain Measurement - drug effects ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Sprague-Dawley ; Reaction Time - drug effects ; Reaction Time - physiology ; Sex Characteristics ; Sex differences
Is Part Of: Physiology & behavior, 2001-02, Vol.72 (3), p.439-447
Description: A number of studies have reported that both the immediate and proactive effects of exposure to a shock stressor are less pronounced in female than in male rats. A separate area of research has demonstrated that female rats are less sensitive to the analgesic effects of morphine than males. Experiments from our laboratory, as well as others, have found that exposure to a context associated with shock (i.e., conditioned fear context) at the time of morphine administration, enhances the analgesic effects of morphine. Since previous studies have exclusively employed male rats, the purpose of Experiment 1 was to determine if a sex difference exists to this context conditioned fear-induced enhancement of morphine-induced analgesia. The findings of Experiment 1 showed that females do not appear to exhibit conditioned fear-induced enhancement of morphine analgesia as compared to males. Experiment 2 demonstrated that females exhibited higher levels of conditioned fear-induced enhancement of morphine analgesia during diestrus I than estrous. Experiment 3 demonstrated that females exhibited lower levels of conditioned analgesia compared to males, while both groups exhibited similar freezing levels. The findings of the present experiments suggest that the sex difference observed in Experiment 1 may be due to differences in conditioned analgesia.
Publisher: Cambridge: Elsevier Inc
Language: English
Identifier: ISSN: 0031-9384
EISSN: 1873-507X
DOI: 10.1016/S0031-9384(00)00426-1
PMID: 11274689
Source: MEDLINE
Alma/SFX Local Collection

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Sex differences in relation to conditioned fear-induced enhancement of morphine analgesia

2001 Elsevier Science Inc. ;2001 INIST-CNRS ;ISSN: 0031-9384 ;EISSN: 1873-507X ;DOI: 10.1016/S0031-9384(00)00426-1 ;PMID: 11274689

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