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Liquid Biopsies: Genotyping Circulating Tumor DNA

Journal of clinical oncology, 2014-02, Vol.32 (6), p.579-586 [Peer Reviewed Journal]

2015 INIST-CNRS ;2014 by American Society of Clinical Oncology 2014 ;ISSN: 0732-183X ;EISSN: 1527-7755 ;DOI: 10.1200/JCO.2012.45.2011 ;PMID: 24449238

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  • Title:
    Liquid Biopsies: Genotyping Circulating Tumor DNA
  • Author: DIAZ, Luis A ; BARDELLI, Alberto
  • Subjects: Biological and medical sciences ; Biology of Neoplasia ; Biopsy ; DNA, Neoplasm - blood ; DNA, Neoplasm - genetics ; Genotype ; Humans ; Medical sciences ; Neoplasms - blood ; Neoplasms - genetics ; Tumors
  • Is Part Of: Journal of clinical oncology, 2014-02, Vol.32 (6), p.579-586
  • Description: Genotyping tumor tissue in search of somatic genetic alterations for actionable information has become routine practice in clinical oncology. Although these sequence alterations are highly informative, sampling tumor tissue has significant inherent limitations; tumor tissue is a single snapshot in time, is subject to selection bias resulting from tumor heterogeneity, and can be difficult to obtain. Cell-free fragments of DNA are shed into the bloodstream by cells undergoing apoptosis or necrosis, and the load of circulating cell-free DNA (cfDNA) correlates with tumor staging and prognosis. Moreover, recent advances in the sensitivity and accuracy of DNA analysis have allowed for genotyping of cfDNA for somatic genomic alterations found in tumors. The ability to detect and quantify tumor mutations has proven effective in tracking tumor dynamics in real time as well as serving as a liquid biopsy that can be used for a variety of clinical and investigational applications not previously possible.
  • Publisher: Alexandria, VA: American Society of Clinical Oncology
  • Language: English
  • Identifier: ISSN: 0732-183X
    EISSN: 1527-7755
    DOI: 10.1200/JCO.2012.45.2011
    PMID: 24449238
  • Source: Geneva Foundation Free Medical Journals at publisher websites
    MEDLINE
    Alma/SFX Local Collection
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