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Case report of transient corneal edema after immunization with adenovirus-vectored COVID-19 vaccine

Medicine (Baltimore), 2022-07, Vol.101 (29), p.e30041 [Peer Reviewed Journal]

Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. ;Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. 2022 ;ISSN: 1536-5964 ;ISSN: 0025-7974 ;EISSN: 1536-5964 ;DOI: 10.1097/MD.0000000000030041 ;PMID: 35866821

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  • Title:
    Case report of transient corneal edema after immunization with adenovirus-vectored COVID-19 vaccine
  • Author: Lee, Jae Yeon ; Han, Sang Beom
  • Subjects: Adenoviridae ; Clinical Case Report ; Corneal Edema - diagnosis ; Corneal Edema - etiology ; Corneal Edema - surgery ; COVID-19 ; COVID-19 Vaccines - adverse effects ; Female ; Humans ; Immunization ; Middle Aged ; Ophthalmic Solutions ; Vaccination - adverse effects
  • Is Part Of: Medicine (Baltimore), 2022-07, Vol.101 (29), p.e30041
  • Description: To report a case of bilateral transient corneal edema presumably associated with adenovirus-vectored coronavirus disease 2019 (COVID-19) vaccination that resolved with eye drops treatment. A 55-year-old Asian woman presented with sudden onset of bilateral visual disturbance developed 6 days after immunization with an adenovirus-vectored COVID-19 vaccine (AstraZeneca, London, United Kingdom). She underwent uneventful cataract surgery in right and left eyes 2 months ago and maintained good visual acuity bilaterally. Slit-lamp examination showed bilateral mild corneal edema that was confirmed with anterior segment optical coherent tomography. Anterior chamber and vitreous were clear bilaterally. Both fundi were normal. The patient was diagnosed with corneal edema following adenovirus-vectored COVID-19 vaccination. She was prescribed with prednisolone acetate 1% eye drops bilaterally. Treatment with topical steroid for 2 weeks resulted in resolution of the corneal edema and improvement of the visual acuity bilaterally. This case suggests that transient corneal edema can develop following adenovirus-vectored COVID-19 vaccination. Prompt ophthalmologic evaluation and treatment may improve the corneal edema.
  • Publisher: United States: Lippincott Williams & Wilkins
  • Language: English
  • Identifier: ISSN: 1536-5964
    ISSN: 0025-7974
    EISSN: 1536-5964
    DOI: 10.1097/MD.0000000000030041
    PMID: 35866821
  • Source: IngentaConnect Open Access
    Open Access: PubMed Central
    Journals@Ovid Open Access Journal Collection Rolling
    DOAJ Directory of Open Access Journals
    MEDLINE
    Wolters Kluwer Open Access
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