skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Results of intravitreal dexamethasone implant (Ozurdex®) for retinal vascular diseases with macular edema: An observational study of real-life situations

Medicine (Baltimore), 2022-07, Vol.101 (27), p.e29807 [Peer Reviewed Journal]

Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. ;Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. 2022 ;ISSN: 1536-5964 ;ISSN: 0025-7974 ;EISSN: 1536-5964 ;DOI: 10.1097/MD.0000000000029807 ;PMID: 35801769

Full text available

Citations Cited by
  • Title:
    Results of intravitreal dexamethasone implant (Ozurdex®) for retinal vascular diseases with macular edema: An observational study of real-life situations
  • Author: Jirarattanasopa, Pichai ; Jiranoppasakdawong, Sakunjanut ; Ratanasukon, Mansing ; Bhurayanontachai, Patama ; Dangboon, Wantanee
  • Subjects: Cataract - complications ; Dexamethasone - therapeutic use ; Diabetic Retinopathy - chemically induced ; Diabetic Retinopathy - complications ; Diabetic Retinopathy - drug therapy ; Drug Implants ; Glucocorticoids - therapeutic use ; Humans ; Intravitreal Injections ; Macular Edema - complications ; Macular Edema - etiology ; Observational Study ; Retinal Vein Occlusion - complications ; Retinal Vein Occlusion - drug therapy ; Retrospective Studies
  • Is Part Of: Medicine (Baltimore), 2022-07, Vol.101 (27), p.e29807
  • Description: To evaluate the efficacy of intravitreal dexamethasone implants (Ozurdex®) for the treatment of macular edema (ME) associated with retinal vascular diseases in real-life situations. This retrospective study included patients with ME associated with retinal vascular occlusion (RVO) or diabetic macular edema (DME) treated with dexamethasone implants. Demographic data, best-corrected visual acuity (BCVA), and central retinal thickness (CRT) at baseline and at 1, 3, and 6 months postoperatively were collected and analyzed, and the adverse events were recorded. Forty-four eyes, 42 patients were included in the study. The mean logMAR BCVA improved from 0.79 ± 0.38 at baseline to 0.60 ± 0.34 (P < 0.001), 0.72 ± 0.38 (P = .002), and 0.72 ± 0.37 (P = .002) at 1, 3, and 6 months, respectively. The CRT decreased from 526.70 ± 159.58 µm at baseline to 279 ± 66.23, 422.91 ± 206.99, and 350.23 ± 151.51 µm at 1, 3, and 6 months, respectively (P < 0.001, all visits). The average number of injections was 1.43 ± 0.5. Nineteen eyes (43.18%) received second injections at an interval of 4.20 ± 0.61 months. The mean logMAR BCVA was greater in RVO than in DME patients and in treatment-naïve eyes than in previously treated ones. The baseline CRT of the reinjection group was significantly higher than that of the single-injection group for both the RVO (P < 0.001) and DME groups (P = .002). Nine eyes (20.45%) with increasing intraocular pressure (IOP) were well controlled with medication, and cataract progression was observed in five eyes (21.73%) during follow-up. The dexamethasone implant was effective for the treatment of macular edema secondary to RVO and DME in terms of visual acuity and CRT improvement over 6 months. The visual acuity was greater in the RVO and treatment-naïve eyes. Reinjection may be associated with a high baseline CRT. The increase in the occurrence of IOP and cataract progression was similar to that reported in previous studies.
  • Publisher: United States: Lippincott Williams & Wilkins
  • Language: English
  • Identifier: ISSN: 1536-5964
    ISSN: 0025-7974
    EISSN: 1536-5964
    DOI: 10.1097/MD.0000000000029807
    PMID: 35801769
  • Source: IngentaConnect Open Access
    Open Access: PubMed Central
    Journals@Ovid Open Access Journal Collection Rolling
    DOAJ Directory of Open Access Journals
    MEDLINE
    Wolters Kluwer Open Access
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait