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Overweight, obesity and the risk of LADA: results from a Swedish case–control study and the Norwegian HUNT Study

Diabetologia, 2018-06, Vol.61 (6), p.1333-1343 [Peer Reviewed Journal]

The Author(s) 2018 ;Diabetologia is a copyright of Springer, (2018). All Rights Reserved. ;ISSN: 0012-186X ;ISSN: 1432-0428 ;EISSN: 1432-0428 ;DOI: 10.1007/s00125-018-4596-0 ;PMID: 29589073

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Title:
Overweight, obesity and the risk of LADA: results from a Swedish case–control study and the Norwegian HUNT Study
Author: Hjort, Rebecka ; Ahlqvist, Emma ; Carlsson, Per-Ola ; Grill, Valdemar ; Groop, Leif ; Martinell, Mats ; Rasouli, Bahareh ; Rosengren, Anders ; Tuomi, Tiinamaija ; Åsvold, Bjørn Olav ; Carlsson, Sofia
Subjects: Adult ; Aged ; ANDIS ; ANDiU ; Autoantibodies - blood ; Autoimmune diseases ; Autoimmunity ; Beta cells ; Body Mass Index ; Body weight ; Case-Control Studies ; Case-control study ; Clinical Medicine ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - epidemiology ; diabetics ; Endocrinology and Diabetes ; Endokrinologi och diabetes ; ESTRID ; Female ; Genotypes ; Glutamate decarboxylase ; Histocompatibility antigen HLA ; Human Physiology ; Humans ; HUNT Study ; Hypotheses ; Insulin ; Insulin Resistance ; Insulin-Secreting Cells - metabolism ; Internal Medicine ; Klinisk medicin ; LADA ; Latent autoimmune diabetes in adults ; Latent Autoimmune Diabetes in Adults - complications ; Latent Autoimmune Diabetes in Adults - diagnosis ; Latent Autoimmune Diabetes in Adults - epidemiology ; Male ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Norway - epidemiology ; Obesity ; Obesity - complications ; Obesity - epidemiology ; Odds Ratio ; Overweight - complications ; Overweight - epidemiology ; Population studies ; Prospective Studies ; Prospective study ; Risk Factors ; Sweden ; Type 2 diabetes ; Young Adult
Is Part Of: Diabetologia, 2018-06, Vol.61 (6), p.1333-1343
Description: Aims/hypothesis Excessive weight is a risk factor for type 2 diabetes, but its role in the promotion of autoimmune diabetes is not clear. We investigated the risk of latent autoimmune diabetes in adults (LADA) in relation to overweight/obesity in two large population-based studies. Methods Analyses were based on incident cases of LADA ( n = 425) and type 2 diabetes ( n = 1420), and 1704 randomly selected control participants from a Swedish case–control study and prospective data from the Norwegian HUNT Study including 147 people with LADA and 1,012,957 person-years of follow-up (1984–2008). We present adjusted ORs and HRs with 95% CI. Results In the Swedish data, obesity was associated with an increased risk of LADA (OR 2.93, 95% CI 2.17, 3.97), which was even stronger for type 2 diabetes (OR 18.88, 95% CI 14.29, 24.94). The association was stronger in LADA with low GAD antibody (GADA;
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
Language: English
Identifier: ISSN: 0012-186X
ISSN: 1432-0428
EISSN: 1432-0428
DOI: 10.1007/s00125-018-4596-0
PMID: 29589073
Source: MEDLINE
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Overweight, obesity and the risk of LADA: results from a Swedish case–control study and the Norwegian HUNT Study

The Author(s) 2018 ;Diabetologia is a copyright of Springer, (2018). All Rights Reserved. ;ISSN: 0012-186X ;ISSN: 1432-0428 ;EISSN: 1432-0428 ;DOI: 10.1007/s00125-018-4596-0 ;PMID: 29589073

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