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Rotating night shift work and risk of type 2 diabetes: two prospective cohort studies in women

PLoS medicine, 2011-12, Vol.8 (12), p.e1001141-e1001141 [Peer Reviewed Journal]

COPYRIGHT 2011 Public Library of Science ;COPYRIGHT 2011 Public Library of Science ;2011 Pan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Pan A, Schernhammer ES, Sun Q, Hu FB (2011) Rotating Night Shift Work and Risk of Type 2 Diabetes: Two Prospective Cohort Studies in Women. PLoS Med 8(12): e1001141. doi:10.1371/journal.pmed.1001141 ;Pan et al. 2011 ;ISSN: 1549-1676 ;ISSN: 1549-1277 ;EISSN: 1549-1676 ;DOI: 10.1371/journal.pmed.1001141 ;PMID: 22162955

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Title:
Rotating night shift work and risk of type 2 diabetes: two prospective cohort studies in women
Author: Pan, An ; Schernhammer, Eva S ; Sun, Qi ; Hu, Frank B
Groop, Leif
Subjects: Adult ; Aged ; Body Mass Index ; Chronic illnesses ; Circadian Rhythm ; Cohort Studies ; Confidence intervals ; Diabetes ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - etiology ; Female ; Follow-Up Studies ; Health aspects ; Health Surveys ; Humans ; Incidence ; Medicine ; Middle Aged ; Night work ; Nurses ; Obesity ; Obesity - epidemiology ; Obesity - etiology ; Prevalence studies (Epidemiology) ; Proportional Hazards Models ; Prospective Studies ; Public health ; Ratios ; Risk ; Risk Factors ; Sensitivity analysis ; Shift work ; Statistical methods ; Studies ; Surveys and Questionnaires ; Time Factors ; Type 2 diabetes ; United States ; Weight Gain ; Womens health ; Work Schedule Tolerance - physiology ; Workers
Is Part Of: PLoS medicine, 2011-12, Vol.8 (12), p.e1001141-e1001141
Description: Rotating night shift work disrupts circadian rhythms and has been associated with obesity, metabolic syndrome, and glucose dysregulation. However, its association with type 2 diabetes remains unclear. Therefore, we aimed to evaluate this association in two cohorts of US women. We followed 69,269 women aged 42-67 in Nurses' Health Study I (NHS I, 1988-2008), and 107,915 women aged 25-42 in NHS II (1989-2007) without diabetes, cardiovascular disease, and cancer at baseline. Participants were asked how long they had worked rotating night shifts (defined as at least three nights/month in addition to days and evenings in that month) at baseline. This information was updated every 2-4 years in NHS II. Self-reported type 2 diabetes was confirmed by a validated supplementary questionnaire. We documented 6,165 (NHS I) and 3,961 (NHS II) incident type 2 diabetes cases during the 18-20 years of follow-up. In the Cox proportional models adjusted for diabetes risk factors, duration of shift work was monotonically associated with an increased risk of type 2 diabetes in both cohorts. Compared with women who reported no shift work, the pooled hazard ratios (95% confidence intervals) for participants with 1-2, 3-9, 10-19, and ≥20 years of shift work were 1.05 (1.00-1.11), 1.20 (1.14-1.26), 1.40 (1.30-1.51), and 1.58 (1.43-1.74, p-value for trend <0.001), respectively. Further adjustment for updated body mass index attenuated the association, and the pooled hazard ratios were 1.03 (0.98-1.08), 1.06 (1.01-1.11), 1.10 (1.02-1.18), and 1.24 (1.13-1.37, p-value for trend <0.001). Our results suggest that an extended period of rotating night shift work is associated with a modestly increased risk of type 2 diabetes in women, which appears to be partly mediated through body weight. Proper screening and intervention strategies in rotating night shift workers are needed for prevention of diabetes.
Publisher: United States: Public Library of Science
Language: English
Identifier: ISSN: 1549-1676
ISSN: 1549-1277
EISSN: 1549-1676
DOI: 10.1371/journal.pmed.1001141
PMID: 22162955
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
Public Library of Science (PLoS)
ProQuest Central
DOAJ Directory of Open Access Journals

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Rotating night shift work and risk of type 2 diabetes: two prospective cohort studies in women

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