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Outdoor air pollution and asthma

The Lancet (British edition), 2014-05, Vol.383 (9928), p.1581-1592 [Peer Reviewed Journal]

Elsevier Ltd ;2014 Elsevier Ltd ;2015 INIST-CNRS ;Copyright © 2014 Elsevier Ltd. All rights reserved. ;Copyright Elsevier Limited May 3, 2014 ;ISSN: 0140-6736 ;EISSN: 1474-547X ;DOI: 10.1016/S0140-6736(14)60617-6 ;PMID: 24792855 ;CODEN: LANCAO

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Title:
Outdoor air pollution and asthma
Author: Guarnieri, Michael, MD ; Balmes, John R, Dr
Subjects: Air Pollutants - analysis ; Air Pollutants - toxicity ; Air pollution ; Air Pollution - adverse effects ; Air Pollution - analysis ; Asthma ; Asthma - etiology ; Biological and medical sciences ; Developing countries ; Environment. Living conditions ; Environmental Exposure - adverse effects ; Environmental protection ; Gases - toxicity ; General aspects ; Health Policy ; Humans ; Internal Medicine ; Kinases ; LDCs ; Medical sciences ; Miscellaneous ; Older people ; Outdoor activities ; Outdoor air quality ; Oxidative stress ; Ozone ; Particulate Matter - analysis ; Particulate Matter - toxicity ; Polycyclic aromatic hydrocarbons ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk assessment ; Risk Factors ; Studies ; Vehicle Emissions - analysis ; Vehicle Emissions - toxicity
Is Part Of: The Lancet (British edition), 2014-05, Vol.383 (9928), p.1581-1592
Description: Summary Traffic and power generation are the main sources of urban air pollution. The idea that outdoor air pollution can cause exacerbations of pre-existing asthma is supported by an evidence base that has been accumulating for several decades, with several studies suggesting a contribution to new-onset asthma as well. In this Series paper, we discuss the effects of particulate matter (PM), gaseous pollutants (ozone, nitrogen dioxide, and sulphur dioxide), and mixed traffic-related air pollution. We focus on clinical studies, both epidemiological and experimental, published in the previous 5 years. From a mechanistic perspective, air pollutants probably cause oxidative injury to the airways, leading to inflammation, remodelling, and increased risk of sensitisation. Although several pollutants have been linked to new-onset asthma, the strength of the evidence is variable. We also discuss clinical implications, policy issues, and research gaps relevant to air pollution and asthma.
Publisher: Kidlington: Elsevier Ltd
Language: English
Identifier: ISSN: 0140-6736
EISSN: 1474-547X
DOI: 10.1016/S0140-6736(14)60617-6
PMID: 24792855
CODEN: LANCAO
Source: ProQuest One Psychology
MEDLINE
ProQuest Central

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Outdoor air pollution and asthma

Elsevier Ltd ;2014 Elsevier Ltd ;2015 INIST-CNRS ;Copyright © 2014 Elsevier Ltd. All rights reserved. ;Copyright Elsevier Limited May 3, 2014 ;ISSN: 0140-6736 ;EISSN: 1474-547X ;DOI: 10.1016/S0140-6736(14)60617-6 ;PMID: 24792855 ;CODEN: LANCAO

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