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Discordance in STING-Induced Activation and Cell Death Between Mouse and Human Dendritic Cell Populations

Frontiers in immunology, 2022-02, Vol.13, p.794776-794776 [Peer Reviewed Journal]

Copyright © 2022 Pang, Daraj, Balka, De Nardo, Macri, Hochrein, Masterman, Tan, Shoppee, Magill, Jahan, Bafit, Zhan, Kile, Lawlor, Radford, Wright and O’Keeffe. ;Copyright © 2022 Pang, Daraj, Balka, De Nardo, Macri, Hochrein, Masterman, Tan, Shoppee, Magill, Jahan, Bafit, Zhan, Kile, Lawlor, Radford, Wright and O’Keeffe 2022 Pang, Daraj, Balka, De Nardo, Macri, Hochrein, Masterman, Tan, Shoppee, Magill, Jahan, Bafit, Zhan, Kile, Lawlor, Radford, Wright and O’Keeffe ;ISSN: 1664-3224 ;EISSN: 1664-3224 ;DOI: 10.3389/fimmu.2022.794776 ;PMID: 35281062

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Title:
Discordance in STING-Induced Activation and Cell Death Between Mouse and Human Dendritic Cell Populations
Author: Pang, Ee Shan ; Daraj, Ghazal ; Balka, Katherine R ; De Nardo, Dominic ; Macri, Christophe ; Hochrein, Hubertus ; Masterman, Kelly-Anne ; Tan, Peck S ; Shoppee, Angus ; Magill, Zoe ; Jahan, Nazneen ; Bafit, Mariam ; Zhan, Yifan ; Kile, Benjamin T ; Lawlor, Kate E ; Radford, Kristen J ; Wright, Mark D ; O'Keeffe, Meredith
Subjects: Animals ; Cell Death ; Cytosol - metabolism ; dendritic cell (DC) ; Dendritic Cells - metabolism ; human dendritic cells ; Humans ; Immunology ; Interferon Type I - metabolism ; interferon-lambda ; Membrane Proteins ; Mice ; Signal Transduction ; STING activation ; type III interferons
Is Part Of: Frontiers in immunology, 2022-02, Vol.13, p.794776-794776
Description: Stimulator of Interferon Genes (STING) is a cytosolic sensor of cyclic dinucleotides (CDNs). The activation of dendritic cells (DC) the STING pathway, and their subsequent production of type I interferon (IFN) is considered central to eradicating tumours in mouse models. However, this contribution of STING in preclinical murine studies has not translated into positive outcomes of STING agonists in phase I & II clinical trials. We therefore questioned whether a difference in human DC responses could be critical to the lack of STING agonist efficacy in human settings. This study sought to directly compare mouse and human plasmacytoid DCs and conventional DC subset responses upon STING activation. We found all mouse and human DC subsets were potently activated by STING stimulation. As expected, Type I IFNs were produced by both mouse and human plasmacytoid DCs. However, mouse and human plasmacytoid and conventional DCs all produced type III IFNs (i.e., IFN-λs) in response to STING activation. Of particular interest, all human DCs produced large amounts of IFN-λ1, not expressed in the mouse genome. Furthermore, we also found differential cell death responses upon STING activation, observing rapid ablation of mouse, but not human, plasmacytoid DCs. STING-induced cell death in murine plasmacytoid DCs occurred in a cell-intrinsic manner and involved intrinsic apoptosis. These data highlight discordance between STING IFN and cell death responses in mouse and human DCs and caution against extrapolating STING-mediated events in mouse models to equivalent human outcomes.
Publisher: Switzerland: Frontiers Media S.A
Language: English
Identifier: ISSN: 1664-3224
EISSN: 1664-3224
DOI: 10.3389/fimmu.2022.794776
PMID: 35281062
Source: PubMed Central (Open access)
Geneva Foundation Free Medical Journals at publisher websites
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DOAJ (Directory of Open Access Journals)

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Discordance in STING-Induced Activation and Cell Death Between Mouse and Human Dendritic Cell Populations

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