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A Randomized Trial of Rosuvastatin in the Prevention of Venous Thromboembolism

The New England journal of medicine, 2009-04, Vol.360 (18), p.1851-1861 [Peer Reviewed Journal]

Copyright © 2009 Massachusetts Medical Society. All rights reserved. ;2009 INIST-CNRS ;2009 Massachusetts Medical Society ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa0900241 ;PMID: 19329822 ;CODEN: NEJMAG

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Title:
A Randomized Trial of Rosuvastatin in the Prevention of Venous Thromboembolism
Author: Glynn, Robert J ; Danielson, Eleanor ; Fonseca, Francisco A.H ; Genest, Jacques ; Gotto, Antonio M ; Kastelein, John J.P ; Koenig, Wolfgang ; Libby, Peter ; Lorenzatti, Alberto J ; MacFadyen, Jean G ; Nordestgaard, Børge G ; Shepherd, James ; Willerson, James T ; Ridker, Paul M
Subjects: Aged ; Biological and medical sciences ; C-Reactive Protein - analysis ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - prevention & control ; Cholesterol, LDL - blood ; Double-Blind Method ; Drug therapy ; Female ; Fluorobenzenes - adverse effects ; Fluorobenzenes - therapeutic use ; General aspects ; Health aspects ; Hemorrhage - chemically induced ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use ; Incidence ; Male ; Medical sciences ; Middle Aged ; Prevention ; Pulmonary Embolism - prevention & control ; Pyrimidines - adverse effects ; Pyrimidines - therapeutic use ; Risk ; Risk factors ; Rosuvastatin ; Rosuvastatin Calcium ; Studies ; Sulfonamides - adverse effects ; Sulfonamides - therapeutic use ; Thromboembolism ; Thrombosis ; Venous Thromboembolism - epidemiology ; Venous Thromboembolism - prevention & control ; Venous Thrombosis - prevention & control
Is Part Of: The New England journal of medicine, 2009-04, Vol.360 (18), p.1851-1861
Description: In this secondary analysis of data from JUPITER, rosuvastatin, as compared with placebo, resulted in a reduced risk of symptomatic venous thromboembolism (including deep-vein thrombosis and pulmonary embolism). In this secondary analysis of data from JUPITER, rosuvastatin, as compared with placebo, resulted in a reduced risk of symptomatic venous thromboembolism (including deep-vein thrombosis and pulmonary embolism). Venous and arterial thrombosis are common, serious, and strongly age-related events that often occur together 1 , 2 and share some risk factors. 3 – 7 Controversies persist regarding the nature and extent of their shared pathways and whether treatments of demonstrated efficacy for one condition, including anticoagulant agents, antiplatelet therapy, thrombolytic agents, and statins, have consistent benefits for the primary or secondary prevention of the other. 8 – 10 The benefits of statins might accrue not only through their effects on lipid levels but also through their influence on thrombosis and inflammation. 11 – 13 Two prospective, observational studies showed that substantial and significant reductions in the . . .
Publisher: Waltham, MA: Massachusetts Medical Society
Language: English
Identifier: ISSN: 0028-4793
EISSN: 1533-4406
DOI: 10.1056/NEJMoa0900241
PMID: 19329822
CODEN: NEJMAG
Source: ProQuest One Psychology
AUTh Library subscriptions: ProQuest Central
MEDLINE
Alma/SFX Local Collection

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A Randomized Trial of Rosuvastatin in the Prevention of Venous Thromboembolism

Copyright © 2009 Massachusetts Medical Society. All rights reserved. ;2009 INIST-CNRS ;2009 Massachusetts Medical Society ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa0900241 ;PMID: 19329822 ;CODEN: NEJMAG

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