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Diabetes, cardiovascular disease and the microcirculation
Cardiovascular diabetology, 2018-04, Vol.17 (1), p.57-57, Article 57
[Peer Reviewed Journal]
The Author(s) 2018 ;ISSN: 1475-2840 ;EISSN: 1475-2840 ;DOI: 10.1186/s12933-018-0703-2 ;PMID: 29669543
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Title:
Diabetes, cardiovascular disease and the microcirculation
Author:
Strain, W David
;
Paldánius, P M
Subjects:
Animals
;
Cardiovascular disease
;
Cardiovascular System - drug effects
;
Cardiovascular System - pathology
;
Cardiovascular System - physiopathology
;
Diabetes Mellitus, Type 2 - diagnosis
;
Diabetes Mellitus, Type 2 - drug therapy
;
Diabetes Mellitus, Type 2 - epidemiology
;
Diabetes Mellitus, Type 2 - physiopathology
;
Diabetic Angiopathies - diagnosis
;
Diabetic Angiopathies - epidemiology
;
Diabetic Angiopathies - physiopathology
;
Diabetic Angiopathies - prevention & control
;
Humans
;
Hypertension
;
Hypertension - diagnosis
;
Hypertension - epidemiology
;
Hypertension - physiopathology
;
Hypertension - prevention & control
;
Hypoglycemic Agents - therapeutic use
;
Microalbuminuria
;
Microcirculation
;
Microcirculation - drug effects
;
Microvascular changes
;
Prevalence
;
Review
;
Risk Factors
;
Treatment Outcome
;
Type 2 diabetes mellitus
Is Part Of:
Cardiovascular diabetology, 2018-04, Vol.17 (1), p.57-57, Article 57
Description:
Cardiovascular disease (CVD) is the leading cause of mortality in people with type 2 diabetes mellitus (T2DM), yet a significant proportion of the disease burden cannot be accounted for by conventional cardiovascular risk factors. Hypertension occurs in majority of people with T2DM, which is substantially more frequent than would be anticipated based on general population samples. The impact of hypertension is considerably higher in people with diabetes than it is in the general population, suggesting either an increased sensitivity to its effect or a confounding underlying aetiopathogenic mechanism of hypertension associated with CVD within diabetes. In this contribution, we aim to review the changes observed in the vascular tree in people with T2DM compared to the general population, the effects of established anti-diabetes drugs on microvascular outcomes, and explore the hypotheses to account for common causalities of the increased prevalence of CVD and hypertension in people with T2DM.
Publisher:
England: BioMed Central
Language:
English
Identifier:
ISSN: 1475-2840
EISSN: 1475-2840
DOI: 10.1186/s12933-018-0703-2
PMID: 29669543
Source:
Open Access: DOAJ Directory of Open Access Journals
SpringerOpen (Open Access)
Geneva Foundation Free Medical Journals at publisher websites
AUTh Library subscriptions: ProQuest Central
MEDLINE
PubMed Central
ROAD: Directory of Open Access Scholarly Resources
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