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Free water modeling of peritumoral edema using multi-fiber tractography: Application to tracking the arcuate fasciculus for neurosurgical planning

PloS one, 2018-05, Vol.13 (5), p.e0197056-e0197056 [Peer Reviewed Journal]

COPYRIGHT 2018 Public Library of Science ;COPYRIGHT 2018 Public Library of Science ;2018 Gong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2018 Gong et al 2018 Gong et al ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0197056 ;PMID: 29746544

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Title:
Free water modeling of peritumoral edema using multi-fiber tractography: Application to tracking the arcuate fasciculus for neurosurgical planning
Author: Gong, Shun ; Zhang, Fan ; Norton, Isaiah ; Essayed, Walid I ; Unadkat, Prashin ; Rigolo, Laura ; Pasternak, Ofer ; Rathi, Yogesh ; Hou, Lijun ; Golby, Alexandra J ; O'Donnell, Lauren J
Yap, Pew-Thian
Subjects: Adult ; Aged ; Anisotropy ; Biology and Life Sciences ; Brain ; Brain cancer ; Brain Edema - diagnostic imaging ; Brain Edema - physiopathology ; Brain Neoplasms - diagnostic imaging ; Brain Neoplasms - physiopathology ; Brain surgery ; Brain tumors ; Cerebral edema ; Cerebral hemispheres ; Diagnostic imaging ; Diffusion Tensor Imaging ; Edema ; Female ; Free water ; Glioma - diagnostic imaging ; Glioma - physiopathology ; Hemispheres ; Humans ; Image acquisition ; Kalman filter ; Kalman filters ; Magnetic resonance imaging ; Male ; Medical imaging ; Medical research ; Medical schools ; Medicine and Health Sciences ; Metastases ; Methods ; Middle Aged ; Models, Neurological ; Neural circuitry ; Neurosurgery ; NMR ; Nuclear magnetic resonance ; Observations ; Parenchyma ; Patients ; Physical Sciences ; Preoperative care ; Research and Analysis Methods ; Retrospective Studies ; Substantia alba ; Surgery ; Tracking ; Tumors
Is Part Of: PloS one, 2018-05, Vol.13 (5), p.e0197056-e0197056
Description: Peritumoral edema impedes the full delineation of fiber tracts due to partial volume effects in image voxels that contain a mixture of cerebral parenchyma and extracellular water. The purpose of this study is to investigate the effect of incorporating a free water (FW) model of edema for white matter tractography in the presence of edema. We retrospectively evaluated 26 consecutive brain tumor patients with diffusion MRI and T2-weighted images acquired presurgically. Tractography of the arcuate fasciculus (AF) was performed using the two-tensor unscented Kalman filter tractography (UKFt) method, the UKFt method with a reduced fiber tracking stopping fractional anisotropy (FA) threshold (UKFt+rFA), and the UKFt method with the addition of a FW compartment (UKFt+FW). An automated white matter fiber tract identification approach was applied to delineate the AF. Quantitative measurements included tract volume, edema volume, and mean FW fraction. Visual comparisons were performed by three experts to evaluate the quality of the detected AF tracts. The AF volume in edematous brain hemispheres was significantly larger using the UKFt+FW method (p<0.0001) compared to UKFt, but not significantly larger (p = 0.0996) in hemispheres without edema. The AF size increase depended on the volume of edema: a significant correlation was found between AF volume affected by (intersecting) edema and AF volume change with the FW model (Pearson r = 0.806, p<0.0001). The mean FW fraction was significantly larger in tracts intersecting edema (p = 0.0271). Compared to the UKFt+rFA method, there was a significant increase of the volume of the AF tract that intersected the edema using the UKFt+FW method, while the whole AF volumes were similar. Expert judgment results, based on the five patients with the smallest AF volumes, indicated that the expert readers generally preferred the AF tract obtained by using the FW model, according to their anatomical knowledge and considering the potential influence of the final results on the surgical route. Our results indicate that incorporating biophysical models of edema can increase the sensitivity of tractography in regions of peritumoral edema, allowing better tract visualization in patients with high grade gliomas and metastases.
Publisher: United States: Public Library of Science
Language: English
Identifier: ISSN: 1932-6203
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0197056
PMID: 29746544
Source: PLoS OA刊
Geneva Foundation Free Medical Journals at publisher websites
AUTh Library subscriptions: ProQuest Central
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Free water modeling of peritumoral edema using multi-fiber tractography: Application to tracking the arcuate fasciculus for neurosurgical planning

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