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Non-Alcoholic Fatty Pancreas in Young Adults and Its Association with Metabolic Co-morbidities

Obesity (Silver Spring, Md.), 2021-12, Vol.29, p.128-129 [Peer Reviewed Journal]

Copyright Blackwell Publishing Ltd. Dec 2021 ;ISSN: 1930-7381 ;EISSN: 1930-739X

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  • Title:
    Non-Alcoholic Fatty Pancreas in Young Adults and Its Association with Metabolic Co-morbidities
  • Author: Garcia-Reyes, Marine ; Betanzos-Robledo, Larissa ; Peterson, Karen ; Roldan-Valadez, Ernest ; Tellez-Rojo, Martha Maria ; Cantoral, Alejandra
  • Subjects: Metabolism ; Young adults
  • Is Part Of: Obesity (Silver Spring, Md.), 2021-12, Vol.29, p.128-129
  • Description: Background: Non-Alcoholic Fatty Pancreas Disease (NAFPD) is a condition defined as the pancreatic fat content associated with body weight and with increased risk of metabolic comorbidities. In Mexico, one of the countries with the highest obesity prevalence globally (35.3%), there is scarce evidence about NAFPD, especially at young ages. This analysis aims to describe the association of overweight/ obesity (OW/OB), Non-Alcoholic Fatty Liver Disease (NAFLD), and Metabolic Syndrome (MetS) with NAFPD. Methods: In a sample of 98 young adults in the Mexico City-based ELEMENT Cohort, conventional abdominal Magnetic Resonance Image (MRI) and spectroscopy were used to quantify pancreatic and liver fat fractions. Anthropometry and fasting blood samples were taken to classify participants with OW/OB and clinical biomarkers of MetS, respectively. We calculated Spearman correlations between pancreatic fat fraction and MetS components. Logistic regression models, adjusted by sex and age, estimated the OR of presenting NAFPD (>6.2%) with the presence of OW/ OB (BMI > 25kg/m2), NAFLD (>5%), and MetS (according to IDF). Results: The participants' mean age was 21.5 years (SD ± 0.5), 56% were males. The median pancreatic fat fraction was 3.1% (IQR 1.715.79), presenting NAFPD 22.4% of the sample, with no differences between sexes. Variables statistically correlated with pancreatic fat were triglycerides, cholesterol, fasting insulin, liver fat, BMI, and waist circumference (rho > 0.3, p < 0.05). The Odds of having NAFPD were 3-times higher in those identified with OW/OB (OR = 3.5, CI 1.2-9.7) or MetS (OR = 3.3, CI 1.05-10.8); and 10-times higher in those with NAFLD (OR = 9.9, CI 3.1-31.2). Conclusions: NAFPD, was a common finding, approximately in 1 of every 5 participants. This clinical entity was significantly associated with NAFLD, OW/OB, and MetS, with no difference in gender. More research is needed, especially in the young population, to early identify its prevalence in a broad sample, lifestyle factors associated, and consequences in health.
  • Publisher: Silver Spring: Blackwell Publishing Ltd
  • Language: English
  • Identifier: ISSN: 1930-7381
    EISSN: 1930-739X
  • Source: ProQuest Central
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